Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | peptide deformylase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0075 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0266 | 0.0914 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.2906 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0106 | 0.2906 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.0279 | 0.8817 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.2906 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 0.8817 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0279 | 0.8817 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0279 | 0.8817 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0313 | 1 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0266 | 0.0266 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0266 | 0.0266 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0075 | 0.0259 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0266 | 0.0301 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0075 | 0.0259 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0313 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0139 | 0.0158 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0139 | 0.0158 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0266 | 0.0914 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0139 | 0.0158 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0139 | 0.0158 |
Echinococcus multilocularis | snurportin 1 | 0.0313 | 1 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0075 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0106 | 0.2906 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0139 | 0.0478 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0279 | 0.8817 | 0.5 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0266 | 0.0266 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0139 | 0.0478 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0075 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 0.8817 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.2906 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0266 | 0.0301 |
Toxoplasma gondii | hypothetical protein | 0.0279 | 0.8817 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0075 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0266 | 0.1253 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0139 | 0.0656 |
Brugia malayi | RNA, U transporter 1 | 0.0083 | 0.2121 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0139 | 0.0139 |
Plasmodium falciparum | peptide deformylase | 0.0279 | 0.8817 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0139 | 0.0478 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.2906 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0266 | 0.0301 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0266 | 0.0266 |
Chlamydia trachomatis | peptide deformylase | 0.0279 | 0.8817 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0139 | 0.0478 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0106 | 0.2906 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 nM | Inhibition of Escherichia coli nickel containing peptide deformylase | ChEMBL. | 21621999 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.