Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Glycogen phosphorylase, muscle form | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Glycogen phosphorylase, muscle form | 843 aa | 840 aa | 70.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0056 | 0.1384 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.6212 | 0.6212 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.2662 | 0.2662 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0111 | 0.4955 | 0.7976 |
Chlamydia trachomatis | glycogen phosphorylase | 0.013 | 0.6212 | 0.5 |
Echinococcus multilocularis | geminin | 0.0188 | 1 | 1 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0056 | 0.1384 | 0.1697 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.4955 | 0.7976 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.6212 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0111 | 0.4955 | 0.7976 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.6212 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.6212 | 0.6212 |
Brugia malayi | Inositol-1 | 0.0041 | 0.0398 | 0.064 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.6212 | 0.6212 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0398 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.013 | 0.6212 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.0398 | 0.0398 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0398 | 0.0398 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0041 | 0.0398 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2662 | 0.4284 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.6212 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.013 | 0.6212 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0076 | 0.2662 | 0.4284 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0037 | 0.0116 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.6212 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.013 | 0.6212 | 0.6212 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0.0398 | 0.5 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.0398 | 0.0398 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.6212 | 0.6212 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.6212 | 0.6212 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0111 | 0.4955 | 0.7976 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.6212 | 0.6212 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.013 | 0.6212 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0056 | 0.1384 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0398 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0398 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0056 | 0.1384 | 0.1384 |
Giardia lamblia | Glycogen phosphorylase | 0.013 | 0.6212 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0056 | 0.1384 | 0.1697 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.0398 | 0.064 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0056 | 0.1384 | 0.1697 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.013 | 0.6212 | 0.6212 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0398 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.59 | Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method | ChEMBL. | 21439694 |
IC50 (binding) | = 2.59 uM | Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method | ChEMBL. | 21439694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.