Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0071 | 0.2742 | 0.3591 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0161 | 0.7637 | 1 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0071 | 0.2742 | 0.2742 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 0.2742 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0071 | 0.2742 | 0.2742 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0 | 0.5 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0205 | 1 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0087 | 0.3616 | 0.3616 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0071 | 0.2742 | 0.3591 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 0.2742 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.7637 | 0.7637 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0205 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0161 | 0.7637 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0041 | 0.111 | 0.1454 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 0.2742 | 1 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0071 | 0.2742 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.7637 | 0.7637 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0205 | 1 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0071 | 0.2742 | 0.2742 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0205 | 1 | 1 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0205 | 1 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0161 | 0.7637 | 0.7637 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0205 | 1 | 0.5 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0041 | 0.111 | 0.1454 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0205 | 1 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0087 | 0.3616 | 0.3616 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0071 | 0.2742 | 0.2742 |
Echinococcus multilocularis | muscleblind protein | 0.0161 | 0.7637 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.6 uM | Inhibition of human recombinant MIF tautomerase activity using 4-hydroxyphenylpyruvate as substrate | ChEMBL. | 21719283 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.