Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peptide deformylase (mitochondrial) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | polypeptide deformylase-like protein, putative | peptide deformylase (mitochondrial) | 243 aa | 207 aa | 27.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | peptide deformylase | 0.0279 | 0.5365 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.0279 | 0.5365 | 1 |
Brugia malayi | glutathione reductase | 0.0036 | 0.0183 | 0.4132 |
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 0.5365 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0279 | 0.5365 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0 | 0.5 |
Chlamydia trachomatis | peptide deformylase | 0.0279 | 0.5365 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0113 | 0.1829 | 0.3177 |
Schistosoma mansoni | tar DNA-binding protein | 0.0048 | 0.0442 | 0.2384 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0215 | 0.3996 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.1688 | 0.4133 |
Echinococcus multilocularis | tar DNA binding protein | 0.0048 | 0.0442 | 0.0442 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0091 | 0.1356 | 0.2264 |
Brugia malayi | Thioredoxin reductase | 0.0036 | 0.0183 | 0.4132 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 0.5365 | 0.5 |
Brugia malayi | RNA binding protein | 0.0048 | 0.0442 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0967 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0102 | 0.1585 | 0.3677 |
Schistosoma mansoni | tar DNA-binding protein | 0.0048 | 0.0442 | 0.2384 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0215 | 0.3996 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0106 | 0.1688 | 0.3947 |
Onchocerca volvulus | 0.0073 | 0.0967 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0048 | 0.0442 | 0.2384 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0036 | 0.0183 | 0.0183 |
Toxoplasma gondii | thioredoxin reductase | 0.0036 | 0.0183 | 0.005 |
Echinococcus multilocularis | tumor protein p63 | 0.0496 | 1 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0073 | 0.0967 | 0.5213 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0082 | 0.1162 | 0.1889 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0082 | 0.1162 | 0.1889 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0102 | 0.1585 | 0.3871 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0036 | 0.0183 | 0.0306 |
Loa Loa (eye worm) | RNA binding protein | 0.0048 | 0.0442 | 0.3308 |
Mycobacterium ulcerans | peptide deformylase | 0.0279 | 0.5365 | 1 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0106 | 0.1688 | 0.4133 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.1688 | 0.4133 |
Brugia malayi | TAR-binding protein | 0.0048 | 0.0442 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0048 | 0.0442 | 0.3308 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0091 | 0.1356 | 0.2264 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0106 | 0.1688 | 0.4133 |
Loa Loa (eye worm) | TAR-binding protein | 0.0048 | 0.0442 | 0.3308 |
Mycobacterium tuberculosis | Probable reductase | 0.0082 | 0.1162 | 0.1889 |
Schistosoma mansoni | tar DNA-binding protein | 0.0048 | 0.0442 | 0.2384 |
Echinococcus granulosus | tar DNA binding protein | 0.0048 | 0.0442 | 0.0442 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0091 | 0.1356 | 0.0463 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0279 | 0.5365 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.1688 | 0.4133 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0036 | 0.0183 | 0.0183 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0048 | 0.0442 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.1688 | 0.4133 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0082 | 0.1162 | 0.1889 |
Toxoplasma gondii | hypothetical protein | 0.0279 | 0.5365 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0102 | 0.1585 | 0.3871 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0091 | 0.1356 | 0.2264 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0215 | 0.3996 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0037 | 0.0203 | 0.0358 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0082 | 0.1162 | 0.1889 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0215 | 0.3996 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0082 | 0.1162 | 0.1889 |
Schistosoma mansoni | tar DNA-binding protein | 0.0048 | 0.0442 | 0.2384 |
Trypanosoma brucei | trypanothione reductase | 0.0036 | 0.0183 | 0.0306 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 uM | Inhibition of human peptide deformylase after 1 hr by fluorescence polarization based competition assay | ChEMBL. | 21719286 |
IC50 (functional) | = 25 uM | Cytotoxicity against human MOLT3 cells | ChEMBL. | 21719286 |
IC50 (functional) | = 28 uM | Cytotoxicity against human Jurkat cells | ChEMBL. | 21719286 |
IC50 (functional) | = 42 uM | Cytotoxicity against human HL60 cells | ChEMBL. | 21719286 |
IC50 (functional) | = 64 uM | Cytotoxicity against human vincristine-resistant HL60 cells | ChEMBL. | 21719286 |
IC50 (binding) | > 100 uM | Inhibition of Escherichia coli peptide deformylase after 1 hr by fluorescence polarization based competition assay | ChEMBL. | 21719286 |
IC50 (ADMET) | = 100 uM | Cytotoxicity against human HEK293 cells | ChEMBL. | 21719286 |
IC50 (functional) | = 100 uM | Cytotoxicity against human Y79 cells | ChEMBL. | 21719286 |
Inhibition (binding) | = 46 % | Inhibition of human recombinant MMP1 at 100 uM after 1 hr by fluorescence polarization based competition assay | ChEMBL. | 21719286 |
Inhibition (binding) | = 53 % | Inhibition of Escherichia coli peptide deformylase at 100 uM after 1 hr by fluorescence polarization based competition assay | ChEMBL. | 21719286 |
Inhibition (binding) | = 96 % | Inhibition of porcine kidney microsomal aminopeptidase N at 100 uM after 1 hr by fluorescence polarization based competition assay | ChEMBL. | 21719286 |
Inhibition (binding) | = 100 % | Inhibition of human peptide deformylase at 100 uM after 1 hr by fluorescence polarization based competition assay | ChEMBL. | 21719286 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.