Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ketohexokinase (fructokinase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_133459 | All targets in OG5_133459 | |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | ribokinase, putative | ketohexokinase (fructokinase) | 298 aa | 307 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0181 | 0.0327 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0181 | 0.0327 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0573 | 0.0573 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0181 | 0.0327 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0573 | 0.0573 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0181 | 0.0327 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0573 | 0.04 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.5516 | 1 |
Echinococcus granulosus | geminin | 0.019 | 0.5516 | 1 |
Echinococcus multilocularis | geminin | 0.019 | 0.5516 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0181 | 0.0327 |
Onchocerca volvulus | 0.0312 | 1 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0181 | 0.0327 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0181 | 0.0181 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0181 | 0.0327 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.5516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0573 | 0.04 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.33 uM | Inhibition of KHK-mediated conversion of D-fructose to fructose-1-phosphate after 60 mins by high throughput mass spectrometry analysis | ChEMBL. | 21767952 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.