Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 3.5 mg kg-1 | Cytoprotective activity in rats against the ethyl alcohol stimulated ulcers measured as effective dose | ChEMBL. | 3669011 |
Inhibition (functional) | = 32 % | Antisecretory activity in histamine stimulated dogs at 2 mg/kg dose administered intravenously | ChEMBL. | 3669011 |
Inhibition (functional) | = 68 % | Antisecretory activity in histamine stimulated dogs at 8 mg/kg dose administered orally | ChEMBL. | 3669011 |
Inhibition (functional) | = 70 % | Antisecretory activity in histamine stimulated dogs following 5 mg/kg i.v. administration. | ChEMBL. | 3669011 |
Inhibition (functional) | = 95 % | Antisecretory activity in pylorus ligated rats at a 40 mg/kg dose administered intraperitoneally | ChEMBL. | 3669011 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.