Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0203 | 0.059 | 0.2042 |
Schistosoma mansoni | hypothetical protein | 0.0128 | 0.0297 | 0.0913 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0345 | 0.115 | 0.1097 |
Schistosoma mansoni | tar DNA-binding protein | 0.0203 | 0.059 | 0.2042 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0345 | 0.115 | 0.6942 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0056 | 0.0012 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0133 | 0.0316 | 0.1877 |
Echinococcus multilocularis | tumor protein p63 | 0.1065 | 0.3983 | 0.3946 |
Echinococcus granulosus | tar DNA binding protein | 0.0203 | 0.059 | 0.1373 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0345 | 0.115 | 0.6942 |
Schistosoma mansoni | hypothetical protein | 0.0128 | 0.0297 | 0.0913 |
Loa Loa (eye worm) | RNA binding protein | 0.0203 | 0.059 | 0.3542 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0345 | 0.115 | 0.4199 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0133 | 0.0316 | 0.0676 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0133 | 0.0316 | 0.0397 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0316 | 0.1877 |
Echinococcus multilocularis | protein dispatched 1 | 0.0152 | 0.0389 | 0.0332 |
Echinococcus multilocularis | GPCR, family 2 | 0.007 | 0.0069 | 0.001 |
Schistosoma mansoni | patched 1 | 0.0133 | 0.0316 | 0.0985 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0056 | 0.0012 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0068 | 0.006 | 0.0325 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0069 | 0.0037 |
Echinococcus multilocularis | geminin | 0.0728 | 0.2656 | 0.2612 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.0667 | 0.4009 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0075 | 0.0086 | 0.0274 |
Echinococcus granulosus | GPCR family 2 | 0.007 | 0.0069 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0069 | 0.0383 |
Loa Loa (eye worm) | phosphofructokinase | 0.0116 | 0.025 | 0.1478 |
Schistosoma mansoni | hypothetical protein | 0.0128 | 0.0297 | 0.0913 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.007 | 0.0069 | 0.0049 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.009 | 0.0044 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0116 | 0.025 | 0.0622 |
Brugia malayi | RNA binding protein | 0.0203 | 0.059 | 0.3542 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0075 | 0.0086 | 0.3283 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.031 | 0.1011 | 1 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0116 | 0.025 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0086 | 0.0485 |
Mycobacterium tuberculosis | Probable histidinol dehydrogenase HisD (HDH) | 0.0743 | 0.2717 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0345 | 0.115 | 0.1097 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0222 | 0.0667 | 0.4009 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0116 | 0.025 | 0.1768 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0203 | 0.059 | 0.3542 |
Echinococcus multilocularis | protein patched | 0.0133 | 0.0316 | 0.0257 |
Echinococcus granulosus | expressed conserved protein | 0.0291 | 0.0937 | 0.2256 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0116 | 0.025 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0075 | 0.0086 | 0.0317 |
Brugia malayi | CHE-14 protein | 0.0133 | 0.0316 | 0.1877 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0203 | 0.059 | 0.3542 |
Mycobacterium ulcerans | histidinol dehydrogenase | 0.0743 | 0.2717 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0222 | 0.0667 | 0.4009 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0116 | 0.025 | 0.0879 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0345 | 0.115 | 0.2797 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.007 | 0.0069 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0086 | 0.0485 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0075 | 0.0086 | 0.0274 |
Echinococcus granulosus | geminin | 0.0728 | 0.2656 | 0.6627 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0086 | 0.0485 |
Schistosoma mansoni | hypothetical protein | 0.0728 | 0.2656 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.1065 | 0.3983 | 1 |
Mycobacterium leprae | Probable histidinol dehydrogenase HisD (HDH) | 0.0743 | 0.2717 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0133 | 0.0316 | 0.0676 |
Brugia malayi | AMP-binding enzyme family protein | 0.0075 | 0.0086 | 0.0485 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.007 | 0.0069 | 0.0049 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.009 | 0.0044 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0156 | 0.0406 | 0.1334 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0314 | 0.103 | 0.3737 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0345 | 0.115 | 0.4199 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0068 | 0.006 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.1011 | 0.6098 |
Onchocerca volvulus | 0.0538 | 0.1911 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0203 | 0.059 | 0.2042 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0116 | 0.025 | 0.1478 |
Brugia malayi | Latrophilin receptor protein 2 | 0.007 | 0.0069 | 0.0383 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0116 | 0.025 | 0.0919 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0345 | 0.115 | 0.2797 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0116 | 0.025 | 0.0191 |
Onchocerca volvulus | 0.0156 | 0.0406 | 0.1871 | |
Brugia malayi | phosphofructokinase | 0.0116 | 0.025 | 0.1478 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.031 | 0.1011 | 0.2444 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0012 | 0.0035 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.007 | 0.0069 | 0.0383 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0056 | 0.0012 | 0.1076 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0075 | 0.0086 | 0.3283 |
Brugia malayi | TAR-binding protein | 0.0203 | 0.059 | 0.3542 |
Trichomonas vaginalis | set domain proteins, putative | 0.0538 | 0.1911 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.007 | 0.0069 | 0.001 |
Brugia malayi | AMP-binding enzyme family protein | 0.0075 | 0.0086 | 0.0485 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.007 | 0.0069 | 0.001 |
Brugia malayi | AMP-binding enzyme family protein | 0.0075 | 0.0086 | 0.0485 |
Loa Loa (eye worm) | TAR-binding protein | 0.0203 | 0.059 | 0.3542 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.009 | 0.0031 |
Brugia malayi | Pre-SET motif family protein | 0.0473 | 0.1654 | 1 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0069 | 0.0037 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0075 | 0.0086 | 0.0274 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0116 | 0.025 | 0.0732 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0133 | 0.0316 | 0.0257 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0116 | 0.025 | 0.1768 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0116 | 0.025 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0473 | 0.1654 | 1 |
Brugia malayi | hypothetical protein | 0.0076 | 0.009 | 0.051 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.009 | 0.0044 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0442 | 0.1534 | 0.3773 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.031 | 0.1011 | 0.6098 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0069 | 0.0037 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.009 | 0.0044 |
Echinococcus multilocularis | expressed conserved protein | 0.0291 | 0.0937 | 0.0883 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0075 | 0.0086 | 0.0274 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.039 | 0.1273 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0116 | 0.025 | 0.0732 |
Mycobacterium ulcerans | hypothetical protein | 0.0075 | 0.0086 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0012 | 0.0035 |
Brugia malayi | 6-phosphofructokinase | 0.0116 | 0.025 | 0.1478 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0012 | 0.0035 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0075 | 0.0086 | 0.0317 |
Schistosoma mansoni | hypothetical protein | 0.0128 | 0.0297 | 0.0913 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.006 | 0.0325 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0069 | 0.0037 |
Echinococcus multilocularis | tar DNA binding protein | 0.0203 | 0.059 | 0.0533 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.009 | 0.0117 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0075 | 0.0086 | 0.0274 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.031 | 0.1011 | 0.0957 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0433 | 0.2591 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0075 | 0.0086 | 0.0274 |
Plasmodium vivax | SET domain protein, putative | 0.0068 | 0.006 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0442 | 0.1534 | 0.1483 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0116 | 0.025 | 0.1478 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.039 | 0.2331 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0012 | 0.0035 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0116 | 0.025 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0152 | 0.039 | 0.2331 |
Schistosoma mansoni | tar DNA-binding protein | 0.0203 | 0.059 | 0.2042 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0222 | 0.0667 | 0.4009 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0116 | 0.025 | 0.0508 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0068 | 0.006 | 0.0025 |
Onchocerca volvulus | 0.0075 | 0.0086 | 0.0143 | |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0406 | 0.2426 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0012 | 0.0035 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0345 | 0.115 | 0.4199 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.009 | 0.0103 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0075 | 0.0086 | 0.3283 |
Schistosoma mansoni | hypothetical protein | 0.0728 | 0.2656 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0075 | 0.0086 | 0.0274 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0116 | 0.025 | 0.1768 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.009 | 0.0117 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0056 | 0.0012 | 0.0044 |
Brugia malayi | 6-phosphofructokinase | 0.0116 | 0.025 | 0.1478 |
Schistosoma mansoni | tar DNA-binding protein | 0.0203 | 0.059 | 0.2042 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.