Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0223 | 0.1004 | 0.8795 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0248 | 0.1142 | 0.9268 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0099 | 0.0315 | 0.0759 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.0506 | 0.2565 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0223 | 0.1004 | 0.8151 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0248 | 0.1142 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0223 | 0.1004 | 0.8151 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0506 | 0.2565 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0098 | 0.0312 | 0.0433 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0248 | 0.1142 | 0.9268 |
Plasmodium vivax | glutathione reductase, putative | 0.0098 | 0.0312 | 0.1215 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0098 | 0.0312 | 0.1215 |
Trypanosoma brucei | trypanothione reductase | 0.0098 | 0.0312 | 0.1215 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0098 | 0.0312 | 0.2531 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0506 | 0.2565 | 1 |
Leishmania major | trypanothione reductase | 0.0098 | 0.0312 | 0.1215 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0098 | 0.0312 | 0.1215 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0098 | 0.0312 | 0.1215 |
Loa Loa (eye worm) | glutathione reductase | 0.0098 | 0.0312 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0223 | 0.1004 | 0.8151 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0248 | 0.1142 | 0.9268 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0098 | 0.0312 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0794 | 0.4153 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0223 | 0.1004 | 0.8151 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0506 | 0.2565 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0223 | 0.1004 | 0.8151 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0506 | 0.2565 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.1348 | 0.7206 | 1 |
Brugia malayi | glutathione reductase | 0.0098 | 0.0312 | 0.0433 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0506 | 0.2565 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0506 | 0.2565 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0794 | 0.4153 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0794 | 0.4153 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0506 | 0.2565 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0223 | 0.1004 | 0.8151 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0265 | 0.1232 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0099 | 0.0315 | 0.0759 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.