Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1000 nM | Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells | ChEMBL. | 12781197 |
EC50 (functional) | = 1000 nM | Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells | ChEMBL. | 12781197 |
Efficacy (functional) | 0 % | Antagonistic efficacy towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells; Not active | ChEMBL. | 12781197 |
Efficacy (functional) | = 87 % | Agonist efficacy towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells | ChEMBL. | 12781197 |
Efficacy (functional) | = 87 % | Agonist efficacy towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells | ChEMBL. | 12781197 |
IC50 (functional) | 0 nM | Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells; Not active | ChEMBL. | 12781197 |
Ki (binding) | = -8.21 | Displacement of [3H]progesterone from Progesterone receptor | ChEMBL. | 16821785 |
Ki (binding) | = 6.1 nM | Binding affinity to human progesterone receptor | ChEMBL. | 12781197 |
Ki (binding) | = 6.1 nM | Binding affinity to human progesterone receptor | ChEMBL. | 12781197 |
Log Ki (binding) | = 8.21 | Displacement of [3H]progesterone from Progesterone receptor | ChEMBL. | 16821785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.