Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bradykinin receptor B2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | bradykinin receptor B2 | 391 aa | 354 aa | 19.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.266 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.5868 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.5303 | 0.5303 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.266 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.5868 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.5868 | 0.5868 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.5868 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.266 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.5868 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.266 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.266 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.5868 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.5868 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.5868 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.266 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.266 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.5303 | 0.36 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.266 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.5868 | 0.5 |
Brugia malayi | hypothetical protein | 0.0024 | 0.266 | 0.266 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 200 nM | Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cells | ChEMBL. | 19552431 |
IC50 (functional) | = 1300 nM | Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilization | ChEMBL. | 19552431 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.