Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | chromobox protein 1 | 0.0067 | 0.0861 | 0.445 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0096 | 0.0969 |
Brugia malayi | Heterochromatin protein 1 | 0.0067 | 0.0861 | 0.0861 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0144 | 0.3068 | 0.2808 |
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 0.0861 | 1 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0144 | 0.3068 | 0.2808 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0067 | 0.0861 | 0.445 |
Mycobacterium ulcerans | thymidylate synthase | 0.0105 | 0.1934 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0148 | 0.3157 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0105 | 0.1934 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0105 | 0.1934 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0043 | 0.0157 | 0.0813 |
Echinococcus multilocularis | chromobox protein 1 | 0.0067 | 0.0861 | 0.445 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0148 | 0.3157 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 0.0861 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.0014 | 0.0014 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0105 | 0.1934 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0043 | 0.0157 | 0.0813 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Onchocerca volvulus | 0.0105 | 0.1934 | 0.6285 | |
Schistosoma mansoni | chromobox protein | 0.0067 | 0.0861 | 0.445 |
Brugia malayi | Dihydrofolate reductase | 0.0043 | 0.0157 | 0.0157 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0387 | 1 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0067 | 0.0861 | 0.0848 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0043 | 0.0157 | 0.0813 |
Brugia malayi | thymidylate synthase | 0.0105 | 0.1934 | 0.1934 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0043 | 0.0157 | 0.0143 |
Loa Loa (eye worm) | thymidylate synthase | 0.0105 | 0.1934 | 0.1922 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0.0361 | 0.41 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0387 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0067 | 0.0861 | 0.445 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0105 | 0.1934 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0148 | 0.3157 | 0.0128 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0096 | 0.0969 |
Mycobacterium tuberculosis | Hypothetical protein | 0.005 | 0.0361 | 0.1148 |
Echinococcus multilocularis | thymidylate synthase | 0.0105 | 0.1934 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0096 | 0.0268 |
Brugia malayi | hypothetical protein | 0.005 | 0.0361 | 0.0361 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0043 | 0.0157 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.459 | 0.4582 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0144 | 0.3068 | 0.2808 |
Echinococcus multilocularis | chromobox protein 1 | 0.0067 | 0.0861 | 0.445 |
Brugia malayi | dihydrofolate reductase family protein | 0.0043 | 0.0157 | 0.0157 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0144 | 0.3068 | 0.2808 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0148 | 0.3157 | 0.0128 |
Onchocerca volvulus | 0.0144 | 0.3068 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0387 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0148 | 0.3157 | 0.29 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0148 | 0.3157 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 5 ug/ml | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro | ChEMBL. | No reference |
IC50 | > 50 ug/ml | DNDI: Cytotoxicity against L929 mouse fibroblasts, CYTO-SP, 24 hour | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | |||
Trypanosoma brucei | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.