Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0177 | 0.5 | 0.5 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0177 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0177 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0177 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0177 | 0.5 | 0.5 | |
Giardia lamblia | Kinase, CDC7 | 0.0177 | 0.5 | 0.5 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0177 | 0.5 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0177 | 0.5 | 0.5 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0177 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0177 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 37.33 % | Analgesic activity against acetic acid-induced writhing in Swiss albino mouse assessed as protection at 20 mg/kg, po | ChEMBL. | 19321237 |
IC50 (binding) | = 2.61595 | Inhibition of MLCK (unknown origin) incubated for 15 mins using [gamma-32P]-ATP by scintillation counting method | ChEMBL. | 26385444 |
IC50 (binding) | = 41.3 uM | Inhibition of MLCK (unknown origin) incubated for 15 mins using [gamma-32P]-ATP by scintillation counting method | ChEMBL. | 26385444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.