Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.645 | 0.5 |
Schistosoma mansoni | nardilysin (M16 family) | 0.0023 | 1 | 1 |
Toxoplasma gondii | toxolysin TLN4 | 0.001 | 0.0812 | 0.0812 |
Toxoplasma gondii | peptidase M16 inactive domain-containing protein | 0.0014 | 0.3475 | 0.3475 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.645 | 0.5 |
Trypanosoma cruzi | peptidase, putative | 0.0023 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.645 | 0.5 |
Schistosoma mansoni | insulysin (M16 family) | 0.0013 | 0.2662 | 0.2662 |
Echinococcus granulosus | 3'partial|nardilysin | 0.0023 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.645 | 0.5 |
Echinococcus multilocularis | insulin degrading enzyme | 0.0023 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.645 | 0.5 |
Toxoplasma gondii | insulysin, putative | 0.0022 | 0.9188 | 0.9188 |
Echinococcus granulosus | insulin degrading enzyme | 0.0023 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.645 | 0.456 |
Echinococcus multilocularis | nardilysin | 0.0023 | 1 | 1 |
Toxoplasma gondii | rhoptry metalloprotease toxolysin TLN1 | 0.0023 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.645 | 0.5 |
Leishmania major | phosphoglycan beta 1,3 galactosyltransferase 5 | 0.0023 | 1 | 1 |
Toxoplasma gondii | sporozoite developmental protein | 0.0023 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.645 | 0.5 |
Schistosoma mansoni | nardilysin (M16 family) | 0.0023 | 1 | 1 |
Echinococcus granulosus | nardilysin | 0.0023 | 1 | 1 |
Chlamydia trachomatis | insulinase family protease III | 0.0023 | 1 | 0.5 |
Schistosoma mansoni | insulysin unit 3 (M16 family) | 0.0023 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.645 | 0.645 |
Echinococcus multilocularis | nardilysin | 0.0023 | 1 | 1 |
Trypanosoma brucei | peptidase, putative | 0.0023 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.645 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.645 | 0.5 |
Schistosoma mansoni | insulysin unit 3 (M16 family) | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | insulin-degrading enzyme | 0.0023 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.645 | 0.645 |
Trypanosoma cruzi | peptidase, putative | 0.0023 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.645 | 0.6137 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.645 | 0.645 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.645 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.