Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cyclin B | 0.2209 | 1 | 1 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0921 | 0.3202 | 0.3202 |
Trypanosoma cruzi | cyclin, putative | 0.2209 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1288 | 0.514 | 0.514 |
Echinococcus granulosus | cyclin b3 | 0.0921 | 0.3202 | 0.3202 |
Trichomonas vaginalis | cyclins, putative | 0.1511 | 0.6313 | 0.4577 |
Echinococcus granulosus | cyclins | 0.0921 | 0.3202 | 0.3202 |
Trichomonas vaginalis | cyclin A, putative | 0.2209 | 1 | 1 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.2209 | 1 | 0.5 |
Trypanosoma cruzi | cyclin 6, putative | 0.2209 | 1 | 0.5 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0921 | 0.3202 | 0.3202 |
Echinococcus multilocularis | cyclin b3 | 0.0921 | 0.3202 | 0.3202 |
Echinococcus granulosus | cyclin B3 1 | 0.0921 | 0.3202 | 0.3202 |
Loa Loa (eye worm) | hypothetical protein | 0.2209 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0921 | 0.3202 | 0.3202 |
Leishmania major | cyclin | 0.2209 | 1 | 0.5 |
Trypanosoma cruzi | cyclin, putative | 0.2209 | 1 | 0.5 |
Onchocerca volvulus | 0.2209 | 1 | 1 | |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.2209 | 1 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0921 | 0.3202 | 0.3202 |
Echinococcus granulosus | cyclin B | 0.2209 | 1 | 1 |
Plasmodium falciparum | cyclin | 0.0921 | 0.3202 | 0.5 |
Echinococcus multilocularis | cyclin B | 0.2209 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.2209 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.2209 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0921 | 0.3202 | 0.3202 |
Trichomonas vaginalis | cyclin B, putative | 0.2209 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.2209 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.2209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2209 | 1 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0921 | 0.3202 | 0.3202 |
Echinococcus multilocularis | cyclin B3 1 | 0.0921 | 0.3202 | 0.3202 |
Echinococcus multilocularis | cyclins | 0.0921 | 0.3202 | 0.3202 |
Echinococcus multilocularis | cyclins | 0.0921 | 0.3202 | 0.3202 |
Echinococcus multilocularis | cyclins | 0.0921 | 0.3202 | 0.3202 |
Echinococcus granulosus | cyclins | 0.0921 | 0.3202 | 0.3202 |
Trichomonas vaginalis | cyclin B, putative | 0.2209 | 1 | 1 |
Entamoeba histolytica | cyclin, putative | 0.2209 | 1 | 1 |
Schistosoma mansoni | cyclin B3 | 0.0921 | 0.3202 | 0.3202 |
Trichomonas vaginalis | cyclins, putative | 0.2209 | 1 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.2209 | 1 | 1 |
Schistosoma mansoni | cyclins | 0.0921 | 0.3202 | 0.3202 |
Echinococcus granulosus | cyclins | 0.0921 | 0.3202 | 0.3202 |
Toxoplasma gondii | hypothetical protein | 0.0699 | 0.2029 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.2209 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0921 | 0.3202 | 0.3202 |
Echinococcus multilocularis | cyclins | 0.0921 | 0.3202 | 0.3202 |
Echinococcus granulosus | cyclins | 0.0921 | 0.3202 | 0.3202 |
Trypanosoma brucei | mitotic cyclin 6 | 0.2209 | 1 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.2209 | 1 | 1 |
Echinococcus granulosus | cyclins | 0.0921 | 0.3202 | 0.3202 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 34 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.