Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0059 | 0.2806 | 0.2806 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0059 | 0.2806 | 0.2806 |
Giardia lamblia | Hypothetical protein | 0.0052 | 0.1972 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2008 | 0.2008 |
Leishmania major | p450 reductase, putative | 0.0059 | 0.2806 | 0.1438 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0059 | 0.2806 | 0.2806 |
Brugia malayi | flavodoxin family protein | 0.0059 | 0.2806 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0059 | 0.2806 | 0.1438 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0059 | 0.2806 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0059 | 0.2806 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0052 | 0.1972 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0059 | 0.2806 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0059 | 0.2806 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0116 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0059 | 0.2806 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0059 | 0.2806 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0059 | 0.2806 | 0.2806 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0059 | 0.2806 | 0.2806 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0059 | 0.2806 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.2806 | 0.2806 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2755 | 0.2755 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0116 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0059 | 0.2806 | 0.2806 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0059 | 0.2806 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.011 | 0.9292 | 0.9292 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0116 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0059 | 0.2806 | 0.5 |
Leishmania major | ion transport protein-like protein | 0.0098 | 0.7769 | 1 |
Trypanosoma cruzi | ion transport protein, putative | 0.0098 | 0.7769 | 1 |
Trypanosoma cruzi | ion transport protein, putative | 0.0098 | 0.7769 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 5 ug/ml | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro | ChEMBL. | No reference |
IC50 | > 10 ug/ml | DNDI: Cytotoxicity against L929 mouse fibroblasts, 72 hour. | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | ||
Trypanosoma brucei | ChEMBL23 | ||
Trypanosoma brucei gambiense |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.