Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0022 | 0.0629 | 0.0629 | |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0103 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0022 | 0.0629 | 0.0629 |
Echinococcus multilocularis | cysteine protease | 0.0022 | 0.0629 | 0.0629 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0103 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0103 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0022 | 0.0629 | 0.0629 |
Echinococcus granulosus | cathepsin l1 | 0.0022 | 0.0629 | 0.0629 |
Onchocerca volvulus | 0.0022 | 0.0629 | 0.0629 | |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0022 | 0.0629 | 0.0629 |
Onchocerca volvulus | Cathepsin L homolog | 0.0022 | 0.0629 | 0.0629 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0022 | 0.0629 | 0.0629 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0022 | 0.0629 | 0.0629 |
Onchocerca volvulus | 0.0022 | 0.0629 | 0.0629 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0022 | 0.0629 | 0.0629 |
Onchocerca volvulus | 0.0022 | 0.0629 | 0.0629 | |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0103 | 1 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0629 | 0.0629 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0629 | 0.0629 |
Onchocerca volvulus | Cathepsin L homolog | 0.0022 | 0.0629 | 0.0629 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0022 | 0.0629 | 0.0629 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0103 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0103 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0022 | 0.0629 | 0.0629 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0103 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0629 | 0.0629 |
Onchocerca volvulus | 0.0022 | 0.0629 | 0.0629 | |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0103 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0629 | 0.0629 |
Onchocerca volvulus | 0.0022 | 0.0629 | 0.0629 | |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0103 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0022 | 0.0629 | 0.0629 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0022 | 0.0629 | 0.0629 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0103 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 0.0629 | 0.0629 | |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0022 | 0.0629 | 0.0629 |
Echinococcus multilocularis | cysteine protease | 0.0022 | 0.0629 | 0.0629 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0103 | 1 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0629 | 0.0629 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0629 | 0.0629 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0103 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0022 | 0.0629 | 0.0629 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0022 | 0.0629 | 0.0629 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0103 | 1 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0103 | 1 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0103 | 1 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0103 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0022 | 0.0629 | 0.0629 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0103 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0103 | 1 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0022 | 0.0629 | 0.0629 |
Onchocerca volvulus | Cathepsin F homolog | 0.0022 | 0.0629 | 0.0629 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0629 | 0.0629 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.