Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cryptococcus neoformans var. neoformans B-3501A | Imidazoleglycerol-phosphate dehydratase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Candida albicans | Imidazole glycerol phosphate dehydratase | Get druggable targets OG5_129258 | All targets in OG5_129258 |
Mycobacterium tuberculosis | Probable imidazole glycerol-phosphate dehydratase HisB | Get druggable targets OG5_129258 | All targets in OG5_129258 |
Candida albicans | Imidazole glycerol phosphate dehydratase | Get druggable targets OG5_129258 | All targets in OG5_129258 |
Mycobacterium ulcerans | imidazoleglycerol-phosphate dehydratase | Get druggable targets OG5_129258 | All targets in OG5_129258 |
Mycobacterium leprae | Probable imidazole glycerol-phosphate dehydratase HisB | Get druggable targets OG5_129258 | All targets in OG5_129258 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Nanchung homolog | Imidazoleglycerol-phosphate dehydratase | 202 aa | 162 aa | 19.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0063 | 0 | 0.5 |
Entamoeba histolytica | protein kinase , putative | 0.0063 | 0 | 0.5 |
Mycobacterium leprae | Probable imidazole glycerol-phosphate dehydratase HisB | 0.0337 | 0.4388 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0063 | 0 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0063 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0688 | 1 | 1 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0063 | 0 | 0.5 |
Loa Loa (eye worm) | TTK protein kinase | 0.0688 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0063 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0063 | 0 | 0.5 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0688 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0063 | 0 | 0.5 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0063 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.4228 | 0.4228 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0688 | 1 | 0.5 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0688 | 1 | 1 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0063 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0688 | 1 | 1 |
Giardia lamblia | Kinase, TTK | 0.0688 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0688 | 1 | 1 |
Toxoplasma gondii | aurora kinase | 0.0063 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0063 | 0 | 0.5 |
Trypanosoma brucei | aurora B kinase | 0.0063 | 0 | 0.5 |
Mycobacterium ulcerans | imidazoleglycerol-phosphate dehydratase | 0.0683 | 0.9928 | 0.5 |
Brugia malayi | hypothetical protein | 0.0327 | 0.4228 | 0.4228 |
Mycobacterium tuberculosis | Probable imidazole glycerol-phosphate dehydratase HisB | 0.0683 | 0.9928 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.7 uM | Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans | ChEMBL. | 10450980 |
IC50 (binding) | = 2.7 uM | Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans | ChEMBL. | 10450980 |
Ki (binding) | = 0.34 uM | Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans | ChEMBL. | 10450980 |
Ki (binding) | = 0.34 uM | Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans | ChEMBL. | 10450980 |
Kis (binding) | = 3.9 uM | Kinetic constant for the inhibition of imidazole glycerol phosphate dehydratase (IGPD) | ChEMBL. | 10450980 |
Kis (binding) | = 3.9 uM | Kinetic constant for the inhibition of imidazole glycerol phosphate dehydratase (IGPD) | ChEMBL. | 10450980 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.