Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | histone deacetylase, putative | 0.0239 | 0.7538 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0301 | 0.9778 | 1 |
Leishmania major | histone deacetylase, putative | 0.0301 | 0.9778 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.6301 | 0.6444 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0301 | 0.9778 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0239 | 0.7538 | 0.5 |
Plasmodium falciparum | histone deacetylase, putative | 0.0301 | 0.9778 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0239 | 0.7538 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0301 | 0.9778 | 0.9699 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0103 | 0.2631 | 0.2691 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0239 | 0.7538 | 0.6865 |
Echinococcus granulosus | histone deacetylase 6 | 0.0301 | 0.9778 | 0.9699 |
Trypanosoma brucei | histone deacetylase 4 | 0.0301 | 0.9778 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0301 | 0.9778 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0301 | 0.9778 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.0301 | 0.9778 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0239 | 0.7538 | 0.7708 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0301 | 0.9778 | 0.9699 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0239 | 0.7538 | 0.5 |
Trypanosoma brucei | histone deacetylase 1 | 0.0239 | 0.7538 | 0.6865 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0301 | 0.9778 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0239 | 0.7538 | 0.7708 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0239 | 0.7538 | 0.6865 |
Trypanosoma brucei | histone deacetylase, putative | 0.0301 | 0.9778 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0301 | 0.9778 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0239 | 0.7538 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0239 | 0.7538 | 0.5 |
Echinococcus granulosus | histone deacetylase 3 | 0.0239 | 0.7538 | 0.6658 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0103 | 0.2631 | 0.5 |
Echinococcus multilocularis | histone deacetylase | 0.0301 | 0.9778 | 0.9699 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0239 | 0.7538 | 0.7708 |
Echinococcus granulosus | histone deacetylase 1 | 0.0239 | 0.7538 | 0.6658 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0239 | 0.7538 | 0.5 |
Loa Loa (eye worm) | histone deacetylase | 0.0301 | 0.9778 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2631 | 0.2691 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0308 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0239 | 0.7538 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0301 | 0.9778 | 0.9699 |
Schistosoma mansoni | histone deacetylase | 0.0239 | 0.7538 | 0.6658 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0239 | 0.7538 | 0.6865 |
Schistosoma mansoni | histone deacetylase | 0.0239 | 0.7538 | 0.6658 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0239 | 0.7538 | 0.6865 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0301 | 0.9778 | 0.9699 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0239 | 0.7538 | 0.7708 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0301 | 0.9778 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0301 | 0.9778 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0239 | 0.7538 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.6079 | 0.6217 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0239 | 0.7538 | 0.6658 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0301 | 0.9778 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0308 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0301 | 0.9778 | 0.9699 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0301 | 0.9778 | 0.9699 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0239 | 0.7538 | 0.6658 |
Brugia malayi | Histone deacetylase 1 | 0.0239 | 0.7538 | 0.7708 |
Brugia malayi | Histone deacetylase family protein | 0.0301 | 0.9778 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0301 | 0.9778 | 1 |
Brugia malayi | histone deacetylase 11 | 0.0103 | 0.2631 | 0.2691 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0239 | 0.7538 | 0.6865 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.7538 | 0.7708 |
Echinococcus granulosus | histone deacetylase | 0.0301 | 0.9778 | 0.9699 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0239 | 0.7538 | 0.5 |
Giardia lamblia | Histone deacetylase | 0.0239 | 0.7538 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0301 | 0.9778 | 0.9699 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-logMIC (functional) | = 2.67 | Antibacterial activity against Escherichia coli after 24 hrs by tube dilution method | ChEMBL. | 19410452 |
-logMIC (functional) | = 2.82 | Antifungal activity against Candida albicans after 48 hrs by tube dilution method | ChEMBL. | 19410452 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.