Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0105 | 0.4655 | 0.8342 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0093 | 0.3779 | 0.3779 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.8405 | 0.8405 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0077 | 0.2687 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.3779 | 0.4602 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0117 | 0.5493 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0618 | 0.0618 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0179 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0439 | 0.0439 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0117 | 0.5493 | 1 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0077 | 0.2687 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0179 | 1 | 1 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0077 | 0.2687 | 0.2687 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0157 | 0.8405 | 0.8405 |
Brugia malayi | Muscleblind-like protein | 0.0157 | 0.8405 | 0.8405 |
Leishmania major | trypanothione reductase | 0.0046 | 0.0439 | 0.1635 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0618 | 0.0618 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0077 | 0.2687 | 0.2687 |
Onchocerca volvulus | 0.0104 | 0.4581 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.3779 | 0.3779 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.0439 | 0.0439 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0077 | 0.2687 | 0.2687 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.8405 | 0.8405 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0105 | 0.4655 | 0.8342 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.3779 | 0.3779 |
Schistosoma mansoni | alpha-glucosidase | 0.0154 | 0.821 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.3779 | 0.4602 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0077 | 0.2687 | 0.2687 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0439 | 0.0439 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0179 | 1 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0077 | 0.2687 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.0439 | 0.1635 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0618 | 0.0618 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0105 | 0.4655 | 0.8342 |
Echinococcus granulosus | muscleblind protein | 0.0157 | 0.8405 | 0.8405 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0179 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.0439 | 0.1635 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0077 | 0.2687 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0105 | 0.4655 | 0.8342 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0077 | 0.2687 | 0.3273 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0077 | 0.2687 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0077 | 0.2687 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0117 | 0.5493 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0077 | 0.2687 | 0.2687 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0117 | 0.5493 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0618 | 0.0618 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.0439 | 0.0439 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0439 | 0.1635 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0077 | 0.2687 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0439 | 0.0439 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.3779 | 0.3779 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0077 | 0.2687 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0154 | 0.821 | 1 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0077 | 0.2687 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0105 | 0.4655 | 0.8342 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0077 | 0.2687 | 0.2687 |
Echinococcus multilocularis | muscleblind protein | 0.0157 | 0.8405 | 0.8405 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0077 | 0.2687 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.3779 | 0.4602 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.3779 | 0.3779 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0105 | 0.4655 | 0.8342 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0093 | 0.3779 | 0.3779 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -23 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.