Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.0657 | 0.0657 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0509 | 1 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0301 | 0.5659 | 0.4338 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0657 | 0.113 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0509 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0159 | 0.267 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0301 | 0.5659 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0509 | 1 | 1 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0509 | 1 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0217 | 0.3889 | 0.3889 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.0657 | 0.0657 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.0762 | 0.0762 |
Mycobacterium ulcerans | glutaminase | 0.0267 | 0.494 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0309 | 0.5813 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0301 | 0.5659 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0509 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1419 | 0.1419 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0762 | 0.0762 |
Schistosoma mansoni | hypothetical protein | 0.0309 | 0.5813 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0657 | 0.113 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.0657 | 0.0657 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0657 | 0.113 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.0657 | 0.113 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0509 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0063 | 0.0657 | 0.0657 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.1419 | 0.1419 |
Echinococcus multilocularis | snurportin 1 | 0.0309 | 0.5813 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0267 | 0.494 | 0.494 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.1419 | 0.1419 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0509 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0301 | 0.5659 | 1 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0509 | 1 | 0.5 |
Brugia malayi | RNA, U transporter 1 | 0.0082 | 0.1066 | 0.1066 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0657 | 0.113 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0762 | 0.1312 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0217 | 0.3889 | 0.3889 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.0657 | 0.0657 |
Loa Loa (eye worm) | glutaminase 2 | 0.0267 | 0.494 | 0.494 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0509 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0657 | 0.113 |
Schistosoma mansoni | glutaminase | 0.0267 | 0.494 | 0.8498 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0143 | 0.2332 | 0.3871 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0509 | 1 | 0.5 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0309 | 0.5813 | 0.5813 |
Loa Loa (eye worm) | glutaminase | 0.0267 | 0.494 | 0.494 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0143 | 0.2332 | 0.3871 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.0657 | 0.0657 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.0657 | 0.113 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.1419 | 0.1419 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0052 | 0.0425 | 0.0358 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.79 uM | Cytotoxicity against human HeLa cells after 1 to 11 days by MTT assay | ChEMBL. | 19072548 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 19072548 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.