Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | 0 % | Tested for in vivo inhibition of galactitol accumulation in the lens of galactose-fed rats at the dose of 24.4 (mg/kg/day); NS=Not significant | ChEMBL. | 8027987 |
Inhibition (functional) | = 68 % | Tested for in vivo inhibition of galactitol accumulation in the sciatic nerve of galactose-fed rats at the dose of 24.4 (mg/kg/day) | ChEMBL. | 8027987 |
Inhibition (binding) | = 82 % | Inhibition of aldose reductase activity in partially purified bovine lens preparation at 10e-5 M | ChEMBL. | 8027987 |
Inhibition (binding) | = 82 % | Inhibition of aldose reductase activity in partially purified bovine lens preparation at 10e-5 M | ChEMBL. | 8027987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.