TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 401.461 | Formula: C23H23N5O2
H donors: 1 H acceptors: 4 LogP: 2.81 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1ccc(cc1)C(c1cccnc1)N1CCC(CC1)NC(=O)c1onc(c1)C
InChi: 1S/C23H23N5O2/c1-16-13-21(30-27-16)23(29)26-20-8-11-28(12-9-20)22(19-3-2-10-25-15-19)18-6-4-17(14-24)5-7-18/h2-7,10,13,15,20,22H,8-9,11-12H2,1H3,(H,26,29)
InChiKey: MXISCTLEHVAHLR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuropeptide s receptor	0.0134	0.4898	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0134	0.4898	1
Schistosoma mansoni	amine GPCR	0.0134	0.4898	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.4898	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.4898	1
Schistosoma mansoni	amine GPCR	0.0134	0.4898	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.4898	1
Schistosoma mansoni	amine GPCR	0.0134	0.4898	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0134	0.4898	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0134	0.4898	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0134	0.4898	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0134	0.4898	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0134	0.4898	1
Onchocerca volvulus		0.0134	0.4898	0.4226
Echinococcus multilocularis	serotonin receptor	0.0134	0.4898	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0134	0.4898	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Echinococcus granulosus	neuropeptide Y receptor	0.0134	0.4898	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0212	0.9793	1
Schistosoma mansoni	histamine h1 receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Echinococcus multilocularis	neuropeptide receptor	0.0134	0.4898	1
Echinococcus granulosus	neuropeptide Y receptor	0.0134	0.4898	1
Schistosoma mansoni	opsin-like receptor	0.0134	0.4898	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0134	0.4898	1
Onchocerca volvulus		0.0134	0.4898	0.4226
Brugia malayi	G protein-coupled receptor	0.0134	0.4898	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0134	0.4898	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0134	0.4898	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0134	0.4898	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0134	0.4898	1
Echinococcus granulosus	serotonin receptor	0.0134	0.4898	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0134	0.4898	1
Onchocerca volvulus		0.0134	0.4898	0.4226
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0134	0.4898	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0134	0.4898	0.4188
Echinococcus granulosus	neuropeptides capa receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Brugia malayi	follicle stimulating hormone receptor	0.0134	0.4898	1
Brugia malayi	AKH receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.4898	1
Schistosoma mansoni	opsin-like receptor	0.0134	0.4898	1
Echinococcus granulosus	fmrfamide receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Schistosoma mansoni	amine GPCR	0.0134	0.4898	1
Onchocerca volvulus		0.0134	0.4898	0.4226
Brugia malayi	hypothetical protein	0.0134	0.4898	1
Onchocerca volvulus		0.0134	0.4898	0.4226
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Echinococcus multilocularis	neuropeptide Y receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Brugia malayi	larval opioid receptor	0.0134	0.4898	1
Echinococcus granulosus	allatostatin A receptor	0.0134	0.4898	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0134	0.4898	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.4898	1
Echinococcus multilocularis	g protein coupled receptor	0.0134	0.4898	1
Brugia malayi	hypothetical protein	0.0134	0.4898	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0134	0.4898	1
Onchocerca volvulus		0.0078	0.1371	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Brugia malayi	G protein-coupled receptor F59B2.13	0.0134	0.4898	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0134	0.4898	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0134	0.4898	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0134	0.4898	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0134	0.4898	0.4188
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Brugia malayi	hypothetical protein	0.0134	0.4898	1
Brugia malayi	Dopamine receptor	0.0134	0.4898	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0134	0.4898	1
Echinococcus granulosus	neuropeptides capa receptor	0.0134	0.4898	1
Brugia malayi	hypothetical protein	0.0134	0.4898	1
Echinococcus multilocularis	allatostatin A receptor	0.0134	0.4898	1
Brugia malayi	RE15519p	0.0134	0.4898	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0134	0.4898	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.4898	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0134	0.4898	1
Schistosoma mansoni	myosin xvIII	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Schistosoma mansoni	neuropeptide receptor	0.0134	0.4898	1
Brugia malayi	hypothetical protein	0.0134	0.4898	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.4898	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0134	0.4898	0.4188
Brugia malayi	hypothetical protein	0.0134	0.4898	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0134	0.4898	1
Brugia malayi	hypothetical protein	0.0134	0.4898	1
Echinococcus multilocularis	g protein coupled receptor	0.0134	0.4898	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Echinococcus granulosus	rhodopsin orphan GPCR	0.0134	0.4898	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0134	0.4898	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0134	0.4898	1
Echinococcus granulosus	neuropeptide receptor	0.0134	0.4898	1
Onchocerca volvulus		0.0134	0.4898	0.4226
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0134	0.4898	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0134	0.4898	1
Schistosoma mansoni	neuropeptide receptor	0.0134	0.4898	1
Echinococcus multilocularis	neuropeptide receptor	0.0134	0.4898	1
Brugia malayi	hypothetical protein	0.0134	0.4898	1
Brugia malayi	Serotonin receptor	0.0134	0.4898	1
Echinococcus multilocularis	orexin receptor type 2	0.0134	0.4898	1
Brugia malayi	sulfakinin receptor protein	0.0134	0.4898	1
Schistosoma mansoni	hypothetical protein	0.0134	0.4898	1
Echinococcus multilocularis	sex peptide receptor	0.0134	0.4898	1
Echinococcus multilocularis	fmrfamide receptor	0.0134	0.4898	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0134	0.4898	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.4898	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0134	0.4898	1
Brugia malayi	Melatonin receptor type 1A	0.0134	0.4898	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0134	0.4898	1
Echinococcus granulosus	g protein coupled receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Echinococcus multilocularis	serotonin receptor	0.0134	0.4898	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0134	0.4898	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0134	0.4898	0.4188
Echinococcus multilocularis	neuropeptide Y receptor	0.0134	0.4898	1
Brugia malayi	ORL1-like opioid receptor	0.0134	0.4898	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Onchocerca volvulus	Adenylate cyclase type 2 homolog	0.0078	0.1371	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0134	0.4898	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0134	0.4898	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0134	0.4898	1
Brugia malayi	neuropeptide F receptor	0.0134	0.4898	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Brugia malayi	G-protein coupled receptor	0.0134	0.4898	1
Echinococcus granulosus	neuropeptide s receptor	0.0134	0.4898	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0134	0.4898	0.4188
Echinococcus granulosus	tm gpcr rhodopsin	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Brugia malayi	putative neuropeptide receptor NPR1	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Onchocerca volvulus		0.0134	0.4898	0.4226
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0134	0.4898	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0134	0.4898	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0134	0.4898	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0134	0.4898	0.4188
Schistosoma mansoni	biogenic amine receptor	0.0134	0.4898	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0134	0.4898	0.4226
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Echinococcus granulosus	neuropeptide receptor A26	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Echinococcus multilocularis	G protein coupled receptor 139	0.0134	0.4898	1
Schistosoma mansoni	amine GPCR	0.0134	0.4898	1
Schistosoma mansoni	adenoreceptor	0.0134	0.4898	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Echinococcus granulosus	somatostatin receptor	0.0134	0.4898	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0134	0.4898	1
Brugia malayi	G-protein coupled receptor	0.0134	0.4898	1
Echinococcus multilocularis	g protein coupled receptor	0.0134	0.4898	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0134	0.4898	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0134	0.4898	1
Echinococcus multilocularis	adenylate cyclase 9	0.0078	0.1371	0.2798
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.4898	1
Echinococcus granulosus	sex peptide receptor	0.0134	0.4898	1
Schistosoma mansoni	neuropeptide receptor	0.0134	0.4898	1
Brugia malayi	neuropeptide F receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Echinococcus multilocularis	g-protein coupled receptor	0.0134	0.4898	1
Echinococcus granulosus	adenylate cyclase 9	0.0078	0.1371	0.2798
Onchocerca volvulus		0.0134	0.4898	0.4226
Schistosoma mansoni	hypothetical protein	0.0134	0.4898	1
Echinococcus granulosus	G protein coupled receptor 139	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0134	0.4898	1
Schistosoma mansoni	hypothetical protein	0.0134	0.4898	1
Onchocerca volvulus		0.0134	0.4898	0.4226
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Brugia malayi	putative neuropeptide receptor	0.0134	0.4898	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0134	0.4898	1
Echinococcus granulosus	g-protein coupled receptor	0.0134	0.4898	1
Echinococcus multilocularis	somatostatin receptor	0.0134	0.4898	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0134	0.4898	0.4188
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.4898	1
Echinococcus granulosus	neuropeptide receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Echinococcus multilocularis	fmrfamide receptor	0.0134	0.4898	1
Onchocerca volvulus		0.0134	0.4898	0.4226
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0134	0.4898	1
Onchocerca volvulus		0.0134	0.4898	0.4226
Onchocerca volvulus		0.0134	0.4898	0.4226
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.4898	1
Echinococcus granulosus	orexin receptor type 2	0.0134	0.4898	1
Schistosoma mansoni	hypothetical protein	0.0134	0.4898	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0134	0.4898	1
Schistosoma mansoni	biogenic amine receptor	0.0134	0.4898	1
Brugia malayi	GnHR receptor homolog	0.0134	0.4898	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0134	0.4898	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0134	0.4898	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.4898	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0134	0.4898	0.4188
Onchocerca volvulus		0.0134	0.4898	0.4226
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Echinococcus granulosus	g protein coupled receptor	0.0134	0.4898	1
Brugia malayi	hypothetical protein	0.0134	0.4898	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0134	0.4898	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0134	0.4898	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0134	0.4898	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0134	0.4898	1
Onchocerca volvulus		0.0134	0.4898	0.4226
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.4898	1
Onchocerca volvulus		0.0134	0.4898	0.4226
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0134	0.4898	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.4898	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0134	0.4898	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Brugia malayi	Dopamine receptor protein 1	0.0134	0.4898	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0134	0.4898	1
Echinococcus granulosus	g protein coupled receptor	0.0134	0.4898	1
Echinococcus granulosus	hypothetical protein	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Loa Loa (eye worm)	TYRA-2 protein	0.0134	0.4898	0.4188
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0134	0.4898	1
Onchocerca volvulus		0.0134	0.4898	0.4226
Schistosoma mansoni	biogenic amine receptor	0.0134	0.4898	1
Onchocerca volvulus		0.0134	0.4898	0.4226
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0134	0.4898	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4898	0.4188
Brugia malayi	Dopamine receptor protein 2	0.0134	0.4898	1
Brugia malayi	Serotonin receptor	0.0134	0.4898	1
Schistosoma mansoni	opsin-like receptor	0.0134	0.4898	1
Schistosoma mansoni	neuropeptide receptor	0.0134	0.4898	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0134	0.4898	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0134	0.4898	0.4188
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0134	0.4898	0.4226
Brugia malayi	hypothetical protein	0.0134	0.4898	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0134	0.4898	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0134	0.4898	0.4188
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0134	0.4898	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.1965 uM	DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro.	ChEMBL.	No reference
IC90 (functional)	= 0.6885 uM	DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma cruzi	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1863038

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1052439