Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0255 | 0.0505 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0103 | 0.2516 | 0.4978 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0255 | 0.0505 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.5248 | 0.5556 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.0255 | 0.0255 |
Schistosoma mansoni | glutamate receptor kainate | 0.0103 | 0.2516 | 0.4978 |
Echinococcus granulosus | glutamate receptor 2 | 0.0257 | 0.8522 | 0.8522 |
Schistosoma mansoni | glutamate receptor kainate | 0.0103 | 0.2516 | 0.4978 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0276 | 0.9242 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.0255 | 0.0255 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0122 | 0.3274 | 0.3274 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0122 | 0.3274 | 0.3274 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0144 | 0.4111 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0154 | 0.4505 | 0.4505 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0295 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0295 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.5248 | 0.5556 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0168 | 0.5054 | 1 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0211 | 0.6726 | 0.6726 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0103 | 0.2516 | 0.2516 |
Echinococcus granulosus | glutamate receptor 1 | 0.0173 | 0.5248 | 0.5248 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0276 | 0.9242 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0103 | 0.2516 | 0.4978 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.3715 | 0.3849 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0257 | 0.8522 | 0.8522 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0154 | 0.4505 | 0.4505 |
Echinococcus granulosus | voltage gated potassium channel | 0.0045 | 0.0255 | 0.0255 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0122 | 0.3274 | 0.3274 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0144 | 0.4111 | 0.5 |
Echinococcus multilocularis | glutamate receptor 4 | 0.0173 | 0.5248 | 0.5248 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0045 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0154 | 0.4505 | 0.4728 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0122 | 0.3274 | 0.6477 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0211 | 0.6726 | 0.6726 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0168 | 0.5054 | 1 |
Echinococcus granulosus | glutamate receptor 4 | 0.0173 | 0.5248 | 0.5248 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0103 | 0.2516 | 0.4978 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0122 | 0.3274 | 0.3274 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0154 | 0.4505 | 0.4728 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0295 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0276 | 0.9242 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0103 | 0.2516 | 0.2516 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0103 | 0.2516 | 0.4978 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0103 | 0.2516 | 0.4978 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0276 | 0.9242 | 0.9242 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0122 | 0.3274 | 0.3274 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.5248 | 0.5556 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0122 | 0.3274 | 0.3274 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0103 | 0.2516 | 0.2515 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -8 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.