Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | sulfite reductase | 0.0029 | 0.2407 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0042 | 0.7743 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0047 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0047 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0047 | 1 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0047 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0047 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0047 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0042 | 0.7743 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0047 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0047 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0047 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0047 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0047 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0047 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0029 | 0.2407 | 0.2407 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0047 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0047 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0024 | 0.0151 | 0.0151 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0047 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0047 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0047 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0047 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0047 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0047 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.