Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0691 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0104 | 0.0423 | 0.0423 |
Brugia malayi | Kringle domain containing protein | 0.0185 | 0.1748 | 0.1748 |
Mycobacterium ulcerans | thymidylate synthase | 0.0104 | 0.0423 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0185 | 0.1748 | 0.1748 |
Echinococcus granulosus | thymidylate synthase | 0.0104 | 0.0423 | 0.2418 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0691 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1748 | 0.1748 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0147 | 0.1116 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0185 | 0.1748 | 0.2904 |
Onchocerca volvulus | 0.0691 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.1748 | 0.1748 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0104 | 0.0423 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0185 | 0.1748 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0185 | 0.1748 | 1 |
Toxoplasma gondii | aspartyl protease ASP5 | 0.028 | 0.3292 | 1 |
Plasmodium vivax | plasmepsin V, putative | 0.0307 | 0.3738 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0691 | 1 | 1 |
Onchocerca volvulus | 0.0613 | 0.8723 | 0.8723 | |
Loa Loa (eye worm) | hypothetical protein | 0.0691 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0185 | 0.1748 | 0.241 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0185 | 0.1748 | 0.1748 |
Echinococcus multilocularis | thymidylate synthase | 0.0104 | 0.0423 | 0.2418 |
Onchocerca volvulus | 0.0104 | 0.0423 | 0.0423 | |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0185 | 0.1748 | 0.241 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0104 | 0.0423 | 0.5 |
Plasmodium falciparum | plasmepsin V | 0.0307 | 0.3738 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0185 | 0.1748 | 1 |
Onchocerca volvulus | 0.0185 | 0.1748 | 0.1748 | |
Brugia malayi | thymidylate synthase | 0.0104 | 0.0423 | 0.0423 |
Loa Loa (eye worm) | thymidylate synthase | 0.0104 | 0.0423 | 0.0423 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0185 | 0.1748 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | % | Inhibition of aldose reductase activity in partially purified bovine lens preparation at 10e-5 M | ChEMBL. | 8027987 |
Inhibition (binding) | NA 0 % | Inhibition of aldose reductase activity in partially purified bovine lens preparation at 10e-5 M | ChEMBL. | 8027987 |
Inhibition (functional) | 0 % | Tested for in vivo inhibition of galactitol accumulation in the lens of galactose-fed rats at the dose of 55.4 (mg/kg/day); NS=Not significant | ChEMBL. | 8027987 |
Inhibition (functional) | 0 % | Tested for in vivo inhibition of galactitol accumulation in the sciatic nerve of galactose-fed rats at the dose of 55.4 (mg/kg/day); NS=Not significant | ChEMBL. | 8027987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.