Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0497 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0497 | 1 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0497 | 1 | 1 |
Onchocerca volvulus | 0.0497 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 1 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0497 | 1 | 1 |
Onchocerca volvulus | 0.0497 | 1 | 1 | |
Onchocerca volvulus | 0.0497 | 1 | 1 | |
Onchocerca volvulus | 0.0497 | 1 | 1 | |
Onchocerca volvulus | 0.0497 | 1 | 1 | |
Onchocerca volvulus | 0.0497 | 1 | 1 | |
Onchocerca volvulus | 0.0497 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.22 uM | DNDI | DNDI. | No reference |
IC50 (functional) | = 3.03 uM | Antimicrobial activity against bloodstream form of Trypanosoma brucei brucei 427 after 48 hrs by alamar blue assay | ChEMBL. | 24978605 |
IC50 (functional) | = 10 uM | Antimicrobial activity against bloodstream form of Trypanosoma brucei rhodesiense STIB 900 after 70 hrs by alamar blue assay | ChEMBL. | 24978605 |
IC50 (functional) | = 36 uM | Antimicrobial activity against erythrocytic stage of Plasmodium falciparum NF54 infected in human washed RBC assessed as [3H]-hypoxanthine incorporation incubated for 48 hrs prior to [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis | ChEMBL. | 24978605 |
IC50 | > 41.67 uM | DNDI: Cytotoxicity against human MRC-5 lung fibroblast cells. | ChEMBL. | No reference |
IC50 (functional) | = 48 uM | Antimicrobial activity against amastigote form of Leishmania donovani MHOM/ET/67/L82 after 70 hrs by alamar blue assay | ChEMBL. | 24978605 |
IC50 (functional) | = 152 uM | Antimicrobial activity against trypomastigote form of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells after 96 hrs by microscopic analysis | ChEMBL. | 24978605 |
Inhibition (functional) | = 80 % | Antimicrobial activity against bloodstream form of Trypanosoma brucei brucei 427 at 10 uM after 48 hrs by alamar blue assay | ChEMBL. | 24978605 |
Potency (functional) | 5.8024 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Trypanosoma brucei gambiense | 24978605 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.