Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | DNA topoisomerase 2 | 0.063193 | 0.783091 | 0.760179 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.063193 | 0.783091 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0571637 | 0.697405 | 0.703865 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0749816 | 0.950626 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0784558 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0784558 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0491457 | 0.583456 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0592697 | 0.727335 | 0.686098 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.063193 | 0.783091 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0571637 | 0.697405 | 0.703865 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0491457 | 0.583456 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.063193 | 0.783091 | 0.760179 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0592697 | 0.727335 | 0.698533 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0299236 | 0.31028 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0394724 | 0.445984 | 0.569518 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0784558 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0592697 | 0.727335 | 0.717574 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.063193 | 0.783091 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0105225 | 0.034561 | 0.0441341 |
Loa Loa (eye worm) | hypothetical protein | 0.0394724 | 0.445984 | 0.569518 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0749816 | 0.950626 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257819 | 0.251421 | 0.321062 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0571637 | 0.697405 | 0.703865 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0198793 | 0.167535 | 0.482281 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0592697 | 0.727335 | 0.717574 |
Giardia lamblia | DNA topoisomerase II | 0.059771 | 0.73446 | 0.5 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0784558 | 1 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.063193 | 0.783091 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0784558 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0749816 | 0.950626 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0749816 | 0.950626 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.063193 | 0.783091 | 0.760179 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0474811 | 0.5598 | 0.493226 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0784558 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0571637 | 0.697405 | 0.703865 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0592697 | 0.727335 | 0.698533 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0435998 | 0.504642 | 0.452316 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0784558 | 1 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.063193 | 0.783091 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0784558 | 1 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0491457 | 0.583456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257819 | 0.251421 | 0.321062 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.063193 | 0.783091 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.063193 | 0.783091 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.063193 | 0.783091 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.063193 | 0.783091 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0571637 | 0.697405 | 0.703865 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4 uM | Antimalarial activity as reduced parasitaemia after 48 hrs against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum W2 infected in type A+ human erythrocytes by flow cytometry | ChEMBL. | 19482476 |
IC50 (ADMET) | = 15 uM | Cytotoxicity against human K562 cells after 72 hrs by flow cytometry | ChEMBL. | 19482476 |
IC50 (ADMET) | = 16 uM | Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay | ChEMBL. | 19482476 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 19482476 | |
Homo sapiens | ChEMBL23 | 19482476 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.