Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable transcriptional regulatory protein | 0.0284 | 1 | 0.5 |
Mycobacterium ulcerans | AraC/XylS family transcriptional regulator | 0.0284 | 1 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0043 | 0.0281 | 1 |
Echinococcus multilocularis | geminin | 0.0175 | 0.5603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0682 | 1 |
Mycobacterium tuberculosis | Transcriptional regulatory protein (probably AraC-family) | 0.0284 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.5603 | 1 |
Mycobacterium ulcerans | transcriptional regulatory protein | 0.0284 | 1 | 0.5 |
Mycobacterium ulcerans | Ada regulatory protein AlkA | 0.0284 | 1 | 0.5 |
Mycobacterium ulcerans | transcriptional regulatory protein | 0.0284 | 1 | 0.5 |
Mycobacterium tuberculosis | Transcriptional regulatory protein | 0.0284 | 1 | 0.5 |
Mycobacterium tuberculosis | Virulence-regulating transcriptional regulator VirS (AraC/XylS family) | 0.0284 | 1 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0053 | 0.0682 | 0.1217 |
Echinococcus granulosus | geminin | 0.0175 | 0.5603 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0053 | 0.0682 | 0.1217 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.5603 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0049 | 0.0519 | 0.0926 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.