Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0253 | 0.4318 | 0.4318 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0283 | 0.048 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0031 | 0.0007 | 0.5 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Mycobacterium ulcerans | glutaminase | 0.0273 | 0.4724 | 0.5 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0545 | 1 | 0.5 |
Brugia malayi | Importin beta-1 subunit | 0.0031 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0007 | 0.0007 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0283 | 0.048 |
Brugia malayi | RNA, U transporter 1 | 0.0087 | 0.1104 | 0.1104 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0545 | 1 | 0.5 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0327 | 0.5767 | 0.5767 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0283 | 0.0283 |
Schistosoma mansoni | glutaminase | 0.0273 | 0.4724 | 0.819 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0545 | 1 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0283 | 0.048 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0545 | 1 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0273 | 0.4724 | 0.4724 |
Echinococcus granulosus | snurportin 1 | 0.0327 | 0.5767 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0253 | 0.4318 | 0.4318 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0545 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0283 | 0.0283 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0031 | 0.0007 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0545 | 1 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0273 | 0.4724 | 0.4724 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0283 | 0.048 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0545 | 1 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0273 | 0.4724 | 0.4724 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0545 | 1 | 1 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0545 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0283 | 0.048 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0283 | 0.048 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0283 | 0.048 |
Schistosoma mansoni | hypothetical protein | 0.0327 | 0.5767 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0545 | 1 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0327 | 0.5767 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 3 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.