Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | telomerase reverse transcriptase | 0.1071 | 0.262 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.1071 | 0.262 | 0.5 |
Mycobacterium ulcerans | DNA polymerase I | 0.0171 | 0.0288 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.1071 | 0.262 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0171 | 0.0288 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0171 | 0.0288 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.1071 | 0.262 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.1071 | 0.262 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1071 | 0.262 | 1 |
Chlamydia trachomatis | DNA polymerase I | 0.0171 | 0.0288 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1071 | 0.262 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.1071 | 0.262 | 1 |
Treponema pallidum | DNA polymerase I (polA) | 0.0171 | 0.0288 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.2851 | 0.7227 | 0.5 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0171 | 0.0288 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MCC (ADMET) | = 100 ug ml-1 | Cytotoxicity against HEL cells assessed as minimum cytotoxic concentration required to cause microscopically detectable alteration in normal cell morphology | ChEMBL. | 19419804 |
MCC (ADMET) | > 100 ug ml-1 | Cytotoxicity against human HeLa cells assessed as minimum cytotoxic concentration required to cause microscopically detectable alteration in normal cell morphology | ChEMBL. | 19419804 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.