Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0441 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0374 | 0.7318 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.7318 | 0.7318 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0441 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0374 | 0.7318 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0441 | 1 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0441 | 1 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0441 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0374 | 0.7318 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 50 ug ml-1 | Inhibitory activity against cytomegalovirus (CMV) AD 169 strain | ChEMBL. | 10377214 |
EC50 (functional) | > 50 ug ml-1 | Inhibitory activity against cytomegalovirus (CMV) Davis strain | ChEMBL. | 10377214 |
EC50 (functional) | > 50 ug ml-1 | Inhibitory activity against varicella zoster virus thymidine kinase (VZV TK+) OKA strain | ChEMBL. | 10377214 |
EC50 (functional) | > 50 ug ml-1 | Inhibitory activity against varicella zoster virus thymidine kinase (VZV TK+) YS strain | ChEMBL. | 10377214 |
EC50 (functional) | > 50 ug ml-1 | Inhibitory activity against varicella zoster virus thymidine kinase (VZV TK-) 07/1 strain | ChEMBL. | 10377214 |
EC50 (functional) | > 50 ug ml-1 | Inhibition of varicella zoster virus thymidine kinase (VZV TK+) YS/R strain | ChEMBL. | 10377214 |
EC50 (functional) | > 50 ug ml-1 | Inhibitory activity against varicella zoster virus thymidine kinase (VZV TK+) OKA strain | ChEMBL. | 10377214 |
EC50 (functional) | > 50 ug ml-1 | Inhibitory activity against varicella zoster virus thymidine kinase (VZV TK+) YS strain | ChEMBL. | 10377214 |
EC50 (functional) | > 50 ug ml-1 | Inhibitory activity against varicella zoster virus thymidine kinase (VZV TK-) 07/1 strain | ChEMBL. | 10377214 |
EC50 (functional) | > 50 ug ml-1 | Inhibition of varicella zoster virus thymidine kinase (VZV TK+) YS/R strain | ChEMBL. | 10377214 |
EC50 (functional) | > 100 ug ml-1 | Inhibion of human immunodeficiency virus type 1 (HIV-1) induced cytopathogenicity in CEM cells | ChEMBL. | 10377214 |
EC50 (functional) | > 100 ug ml-1 | Inhibion of human immunodeficiency virus type 2 (HIV-2) induced cytopathogenicity in CEM cells | ChEMBL. | 10377214 |
EC50 (functional) | > 200 ug ml-1 | Inhibitory activity against murine sarcoma virus induced transformation of murine C3H/3T3 embryo fibroblasts | ChEMBL. | 10377214 |
EC50 (functional) | > 400 ug ml-1 | Inhibitory activity against herpes simplex virus type 1 (HSV-1) KOS strain | ChEMBL. | 10377214 |
EC50 (functional) | > 400 ug ml-1 | Inhibitory activity against herpes simplex virus type 2 (HSV-2) G strain | ChEMBL. | 10377214 |
EC50 (functional) | > 400 ug ml-1 | Inhibition of herpes simplex virus type 1 thymidine kinase (HSV-1 TK-) B2006 strain | ChEMBL. | 10377214 |
EC50 (functional) | > 400 ug ml-1 | Inhibitory activity against herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) VMW 1837 strain | ChEMBL. | 10377214 |
EC50 (functional) | > 400 ug ml-1 | Inhibitory activity against vaccinia virus (VV) | ChEMBL. | 10377214 |
EC50 (functional) | > 400 ug ml-1 | Inhibition of herpes simplex virus type 1 thymidine kinase (HSV-1 TK-) B2006 strain | ChEMBL. | 10377214 |
EC50 (functional) | > 400 ug ml-1 | Inhibitory activity against herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) VMW 1837 strain | ChEMBL. | 10377214 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.