Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.0308 | 0.0232 | 0.0251 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0308 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.0232 | 0.0251 |
Onchocerca volvulus | 0.0308 | 0.0232 | 0.0251 | |
Brugia malayi | Muscle positioning protein 4 | 0.0377 | 0.0735 | 0.0794 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0679 | 0.2941 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.0232 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0679 | 0.2941 | 0.3177 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0308 | 0.0232 | 0.0251 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0308 | 0.0232 | 0.0232 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0308 | 0.0232 | 0.0232 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0308 | 0.0232 | 0.0232 |
Toxoplasma gondii | PAN domain-containing protein | 0.1272 | 0.7278 | 1 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0308 | 0.0232 | 0.0251 |
Brugia malayi | Trypsin family protein | 0.1543 | 0.9255 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0518 | 0.1765 | 0.1907 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0308 | 0.0232 | 0.0232 |
Onchocerca volvulus | 0.0308 | 0.0232 | 0.0251 | |
Onchocerca volvulus | 0.1234 | 0.6999 | 0.7563 | |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.0232 | 0.0251 |
Onchocerca volvulus | 0.0679 | 0.2941 | 0.3177 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0308 | 0.0232 | 0.0232 |
Brugia malayi | Kringle domain containing protein | 0.0679 | 0.2941 | 0.3177 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0518 | 0.1765 | 0.1907 |
Schistosoma mansoni | hypothetical protein | 0.0308 | 0.0232 | 0.0232 |
Onchocerca volvulus | 0.0308 | 0.0232 | 0.0251 | |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0518 | 0.1765 | 0.5659 |
Brugia malayi | hypothetical protein | 0.0308 | 0.0232 | 0.0251 |
Loa Loa (eye worm) | trypsin family protein | 0.0308 | 0.0232 | 0.0251 |
Leishmania major | hypothetical protein, conserved | 0.0679 | 0.2941 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0308 | 0.0232 | 0.0232 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0679 | 0.2941 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0308 | 0.0232 | 0.0232 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0679 | 0.2941 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0679 | 0.2941 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0518 | 0.1765 | 0.1907 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1543 | 0.9255 | 0.9255 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0518 | 0.1765 | 0.1765 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0308 | 0.0232 | 0.0232 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0308 | 0.0232 | 0.0232 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0308 | 0.0232 | 0.0232 |
Brugia malayi | Trypsin family protein | 0.0308 | 0.0232 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.0232 | 0.0251 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0308 | 0.0232 | 0.0232 |
Toxoplasma gondii | PAN domain-containing protein | 0.1272 | 0.7278 | 1 |
Onchocerca volvulus | 0.0377 | 0.0735 | 0.0794 | |
Echinococcus granulosus | tissue type plasminogen activator | 0.0679 | 0.2941 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0679 | 0.2941 | 0.2941 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0308 | 0.0232 | 0.0232 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0337 | 0.0444 | 0.0444 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.036 | 0.0609 | 0.0609 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0518 | 0.1765 | 0.5659 |
Loa Loa (eye worm) | hypothetical protein | 0.1543 | 0.9255 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0308 | 0.0232 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0308 | 0.0232 | 0.0232 |
Brugia malayi | Protein kinase domain containing protein | 0.0679 | 0.2941 | 0.3177 |
Schistosoma mansoni | hypothetical protein | 0.0308 | 0.0232 | 0.0232 |
Brugia malayi | Trypsin family protein | 0.0308 | 0.0232 | 0.0251 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0308 | 0.0232 | 0.0232 |
Onchocerca volvulus | 0.0308 | 0.0232 | 0.0251 | |
Onchocerca volvulus | 0.1543 | 0.9255 | 1 | |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0679 | 0.2941 | 0.3177 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.0735 | 0.0794 |
Onchocerca volvulus | 0.0308 | 0.0232 | 0.0251 | |
Loa Loa (eye worm) | hypothetical protein | 0.1543 | 0.9255 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0308 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.0232 | 0.0251 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log KB (binding) | = 7.85 | In vitro inhibition of Histamine H2 receptor by measuring its ability to block dimaprit-stimulated chronotropic response of guinea pig atrium strips | ChEMBL. | 6121913 |
-Log KB (binding) | = 7.85 | In vitro inhibition of Histamine H2 receptor by measuring its ability to block dimaprit-stimulated chronotropic response of guinea pig atrium strips | ChEMBL. | 6121913 |
ED50 (functional) | = 0.05 mg kg-1 | Inhibition of acid output in dogs (iv) | ChEMBL. | 6121913 |
ED50 (functional) | = 0.3 mg kg-1 | Inhibition of acid output in dogs (po) | ChEMBL. | 6121913 |
Ratio (functional) | = 6 | Ratio (po/iv) value of the compound | ChEMBL. | 6121913 |
Slope (binding) | = 1.03 | Slope value of the compound | ChEMBL. | 6121913 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.