Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.0884 | 0.0946 |
Mycobacterium ulcerans | hypothetical protein | 0.0333 | 0.0884 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0212 | 0.0161 | 0.0173 |
Brugia malayi | Protein kinase domain containing protein | 0.0737 | 0.3285 | 0.3518 |
Onchocerca volvulus | 0.0333 | 0.0884 | 0.0787 | |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0185 | 0 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0368 | 0.1089 | 0.3316 |
Loa Loa (eye worm) | hypothetical protein | 0.1755 | 0.9338 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0523 | 0.2013 | 0.2155 |
Brugia malayi | Trypsin family protein | 0.0333 | 0.0884 | 0.0946 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0333 | 0.0884 | 0.0884 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0333 | 0.0884 | 0.269 |
Brugia malayi | Trypsin family protein | 0.1755 | 0.9338 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0397 | 0.1265 | 0.385 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.1301 | 0.1393 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0333 | 0.0884 | 0.0884 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1755 | 0.9338 | 0.9338 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0737 | 0.3285 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0185 | 0 | 0.5 |
Onchocerca volvulus | 0.0302 | 0.0697 | 0.0584 | |
Giardia lamblia | Kinase, CMGC CDK | 0.0185 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.0496 | 0.0531 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0368 | 0.1089 | 0.3316 |
Onchocerca volvulus | 0.0333 | 0.0884 | 0.0787 | |
Onchocerca volvulus | 0.0302 | 0.0697 | 0.0584 | |
Onchocerca volvulus | 0.0302 | 0.0697 | 0.0584 | |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0523 | 0.2013 | 0.6127 |
Schistosoma mansoni | hypothetical protein | 0.0302 | 0.0697 | 0.0697 |
Toxoplasma gondii | PAN domain-containing protein | 0.1282 | 0.6526 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0333 | 0.0884 | 0.0884 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0333 | 0.0884 | 0.0884 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0333 | 0.0884 | 0.269 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0213 | 0.0169 | 0.0169 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0333 | 0.0884 | 0.0884 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0333 | 0.0884 | 0.0884 |
Brugia malayi | Muscle positioning protein 4 | 0.0403 | 0.1301 | 0.1393 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0333 | 0.0884 | 0.0884 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0185 | 0 | 0.5 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0185 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0397 | 0.1265 | 0.1265 |
Echinococcus granulosus | enteropeptidase | 0.0333 | 0.0884 | 0.269 |
Echinococcus granulosus | Mastin | 0.0333 | 0.0884 | 0.269 |
Toxoplasma gondii | kringle domain-containing protein | 0.0737 | 0.3285 | 0.5034 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0333 | 0.0884 | 0.269 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0737 | 0.3285 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0185 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0333 | 0.0884 | 0.0946 |
Brugia malayi | Kringle domain containing protein | 0.0737 | 0.3285 | 0.3518 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0161 | 0.0173 |
Schistosoma mansoni | thyroid hormone receptor | 0.0397 | 0.1265 | 0.1265 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0333 | 0.0884 | 0.269 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0185 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.0697 | 0.0747 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0333 | 0.0884 | 0.0884 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0523 | 0.2013 | 0.2013 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 0.0884 | 0.0884 |
Onchocerca volvulus | 0.0737 | 0.3285 | 0.3404 | |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0302 | 0.0697 | 0.0747 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0737 | 0.3285 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0333 | 0.0884 | 0.0884 |
Onchocerca volvulus | 0.0333 | 0.0884 | 0.0787 | |
Brugia malayi | Trypsin family protein | 0.0333 | 0.0884 | 0.0946 |
Toxoplasma gondii | PAN domain-containing protein | 0.1282 | 0.6526 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0333 | 0.0884 | 0.0884 |
Onchocerca volvulus | 0.0302 | 0.0697 | 0.0584 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0333 | 0.0884 | 0.0884 |
Loa Loa (eye worm) | trypsin family protein | 0.0333 | 0.0884 | 0.0946 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0523 | 0.2013 | 0.2155 |
Onchocerca volvulus | 0.1755 | 0.9338 | 1 | |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0523 | 0.2013 | 0.6127 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0737 | 0.3285 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0737 | 0.3285 | 1 |
Onchocerca volvulus | 0.0333 | 0.0884 | 0.0787 | |
Brugia malayi | Trypsin-like protease protein 5 | 0.0333 | 0.0884 | 0.0946 |
Echinococcus granulosus | Tolloid protein 1 | 0.0213 | 0.0169 | 0.0514 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0737 | 0.3285 | 1 |
Echinococcus multilocularis | enteropeptidase | 0.0333 | 0.0884 | 0.269 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0737 | 0.3285 | 0.3518 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.0884 | 0.0946 |
Brugia malayi | SEA domain containing protein | 0.0302 | 0.0697 | 0.0747 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.0884 | 0.0946 |
Brugia malayi | Trypsin family protein | 0.0333 | 0.0884 | 0.0946 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.0884 | 0.0946 |
Schistosoma mansoni | hypothetical protein | 0.0737 | 0.3285 | 0.3285 |
Onchocerca volvulus | 0.0403 | 0.1301 | 0.1241 | |
Giardia lamblia | Kinase, CMGC CDK | 0.0185 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.039 | 0.1218 | 0.1218 |
Schistosoma mansoni | hypothetical protein | 0.0368 | 0.1089 | 0.1089 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0333 | 0.0884 | 0.0884 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0213 | 0.0169 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.0884 | 0.0946 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0333 | 0.0884 | 0.269 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0338 | 0.0909 | 0.0909 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 0.0884 | 0.0884 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0213 | 0.0169 | 0.0514 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0333 | 0.0884 | 0.269 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0523 | 0.2013 | 0.2017 |
Loa Loa (eye worm) | hypothetical protein | 0.1755 | 0.9338 | 1 |
Onchocerca volvulus | 0.1422 | 0.7356 | 0.784 | |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0169 | 0.0181 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0333 | 0.0884 | 0.269 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0333 | 0.0884 | 0.0884 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0333 | 0.0884 | 0.0884 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0333 | 0.0884 | 0.0884 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0333 | 0.0884 | 0.0884 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0185 | 0 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0212 | 0.0161 | 0.0173 |
Echinococcus multilocularis | Mastin | 0.0333 | 0.0884 | 0.269 |
Onchocerca volvulus | 0.0333 | 0.0884 | 0.0787 | |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0333 | 0.0884 | 0.269 |
Loa Loa (eye worm) | hypothetical protein | 0.0737 | 0.3285 | 0.3518 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0333 | 0.0884 | 0.0946 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ISA (functional) | Tested for intrinsic sympathomimetic activity (ISA); Antagonist with partial agonistic properties | ChEMBL. | 2903243 | |
ISA (functional) | 0 | Tested for intrinsic sympathomimetic activity (ISA); Antagonist with partial agonistic properties | ChEMBL. | 2903243 |
Selectivity (binding) | Selectivity of the compound towards beta-2 adrenergic receptor; Nonselective towards beta-2 adrenergic receptor | ChEMBL. | 2903243 | |
Selectivity (binding) | Selectivity for beta-1 adrenergic receptor | ChEMBL. | 2903243 | |
Selectivity (binding) | 0 | Selectivity for beta-1 adrenergic receptor | ChEMBL. | 2903243 |
Selectivity (binding) | 0 | Selectivity of the compound towards beta-2 adrenergic receptor; Nonselective towards beta-2 adrenergic receptor | ChEMBL. | 2903243 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.