Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thioredoxin | 0.00409799 | 0.5 | 0.5 |
Plasmodium vivax | thioredoxin 1, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Trypanosoma cruzi | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin m(mitochondrial)-type, putative | 0.00409799 | 0.5 | 0.5 |
Plasmodium falciparum | thioredoxin 1 | 0.00409799 | 0.5 | 0.5 |
Leishmania major | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Entamoeba histolytica | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Entamoeba histolytica | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Echinococcus multilocularis | thioredoxin | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Toxoplasma gondii | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Entamoeba histolytica | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Mycobacterium ulcerans | thioredoxin TrxC | 0.00409799 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable thioredoxin TrxB1 | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin f-type, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Toxoplasma gondii | thioredoxin-like protein TLP1 | 0.00409799 | 0.5 | 0.5 |
Treponema pallidum | thioredoxin (trx) | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | thioredoxin | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin m(mitochondrial)-type, putative | 0.00409799 | 0.5 | 0.5 |
Mycobacterium ulcerans | thioredoxin TrxB1 | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Echinococcus granulosus | thioredoxin | 0.00409799 | 0.5 | 0.5 |
Echinococcus granulosus | thioredoxin 2 | 0.00409799 | 0.5 | 0.5 |
Echinococcus multilocularis | thioredoxin, mitochondrial | 0.00409799 | 0.5 | 0.5 |
Trypanosoma brucei | thioredoxin | 0.00409799 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00409799 | 0.5 | 0.5 |
Echinococcus multilocularis | thioredoxin 1 | 0.00409799 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Thioredoxin TrxC (TRX) (MPT46) | 0.00409799 | 0.5 | 0.5 |
Schistosoma mansoni | thioredoxin 2 | 0.00409799 | 0.5 | 0.5 |
Echinococcus granulosus | Thioredoxin fold | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin m(mitochondrial)-type, putative | 0.00409799 | 0.5 | 0.5 |
Echinococcus granulosus | thioredoxin mitochondrial | 0.00409799 | 0.5 | 0.5 |
Trypanosoma cruzi | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin f-type, putative | 0.00409799 | 0.5 | 0.5 |
Brugia malayi | thioredoxin | 0.00409799 | 0.5 | 0.5 |
Echinococcus granulosus | thioredoxin 1 | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.00409799 | 0.5 | 0.5 |
Chlamydia trachomatis | thioredoxin | 0.00409799 | 0.5 | 0.5 |
Mycobacterium ulcerans | thioredoxin TrxB1 | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin m(mitochondrial)-type, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | thioredoxin f-type, putative | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.00409799 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.00409799 | 0.5 | 0.5 |
Echinococcus multilocularis | thioredoxin 2 | 0.00409799 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 1.3 mg kg-1 | Effective dose after subcutaneous administration in a mouse malaria model against Plasmodium berghei N strain for 50% inhibition | ChEMBL. | 12213073 |
ED50 (functional) | = 1.8 mg kg-1 | Effective dose after peroral administration in a mouse malaria model against Plasmodium berghei N strain for 50% inhibition | ChEMBL. | 12213073 |
ED50 (functional) | = 2.2 mg kg-1 | Effective dose after sc administration against Plasmodium yoelii sspNS for 50%inhibition in presence of SSV | ChEMBL. | 12213073 |
ED50 (functional) | = 2.3 mg kg-1 | Effective dose after oral administration against Plasmodium yoelii sspNS for 50%inhibition in presence of DMSO | ChEMBL. | 12213073 |
ED90 (functional) | = 2 mg kg-1 | Effective dose after subcutaneous administration in a mouse malaria model against Plasmodium berghei N strain for 90% inhibition | ChEMBL. | 12213073 |
ED90 (functional) | = 5.7 mg kg-1 | Effective dose after peroral administration in a mouse malaria model against Plasmodium berghei N strain for 90% inhibition | ChEMBL. | 12213073 |
ED90 (functional) | = 6.5 mg kg-1 | Effective dose after sc administration against Plasmodium yoelii sspNS for 90%inhibition in presence of SSV | ChEMBL. | 12213073 |
ED90 (functional) | = 7.5 mg kg-1 | Effective dose after oral administration against Plasmodium yoelii sspNS for 90%inhibition in presence of DMSO | ChEMBL. | 12213073 |
IC50 (functional) | = 0.82 ng ml-1 | Inhibitory activity against Plasmodium falciparum D6 strain | ChEMBL. | 12213073 |
IC50 (functional) | = 3.2 ng ml-1 | Inhibitory activity against Plasmodium falciparum K1 strain | ChEMBL. | 12213073 |
IC50 (functional) | = 6.5 ng ml-1 | Inhibitory activity against Plasmodium falciparum W2 strain | ChEMBL. | 12213073 |
NT (functional) | Inhibitory activity against Plasmodium falciparum NF54 strain; Not tested | ChEMBL. | 12213073 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 12213073 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.