Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0095 | 1 | 0.5 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0095 | 1 | 0.5 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0095 | 1 | 1 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0095 | 1 | 0.5 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0095 | 1 | 0.5 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0095 | 1 | 0.5 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0095 | 1 | 1 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0095 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0095 | 1 | 0.5 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0095 | 1 | 1 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0095 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.