Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Monoamine oxidase A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | Monoamine oxidase A | 526 aa | 464 aa | 21.6 % |
Dictyostelium discoideum | amine oxidase | Monoamine oxidase A | 526 aa | 491 aa | 31.0 % |
Dictyostelium discoideum | hypothetical protein | Monoamine oxidase A | 526 aa | 518 aa | 22.4 % |
Dictyostelium discoideum | hypothetical protein | Monoamine oxidase A | 526 aa | 524 aa | 22.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0634 | 1 | 1 | |
Echinococcus granulosus | hexokinase | 0.0634 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0634 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0634 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0634 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0634 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0634 | 1 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0.084 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0634 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0634 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0634 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0432 | 0.3296 | 0.1468 |
Toxoplasma gondii | hexokinase | 0.0634 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0634 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0634 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0634 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0634 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0634 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0634 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0333 | 0 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0634 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0634 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0634 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0634 | 1 | 0.5 |
Onchocerca volvulus | 0.0634 | 1 | 1 | |
Echinococcus multilocularis | hexokinase | 0.0634 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0634 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0634 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0634 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0634 | 1 | 0.5 |
Onchocerca volvulus | 0.0634 | 1 | 1 | |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0.084 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0634 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.02 uM | Inhibitory activity against monoamine oxidase A (MAO A) from rat brain using a radiometric procedure with [3H]-5-HT | ChEMBL. | 8027990 |
IC50 (binding) | = 0.02 uM | Inhibitory activity against monoamine oxidase A (MAO A) from rat brain using a radiometric procedure with [3H]-5-HT | ChEMBL. | 8027990 |
Inhibition (binding) | = -7 % | Inhibitory activity against monoamine oxidase B (MAO B) from rat brain using a radiometric procedure with [14C]-phenylethylamine at 10 uM | ChEMBL. | 8027990 |
Inhibition (binding) | = -7 % | Inhibitory activity against monoamine oxidase B (MAO B) from rat brain using a radiometric procedure with [14C]-phenylethylamine at 10 uM | ChEMBL. | 8027990 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.