Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nmda type glutamate receptor | 0.0372 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0149 | 0.328 | 0.328 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0119 | 0.2393 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0119 | 0.2393 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0318 | 0.8382 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0119 | 0.2393 | 0.2393 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0119 | 0.2393 | 0.2635 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0119 | 0.2393 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0235 | 0.5889 | 0.5889 |
Onchocerca volvulus | 0.0048 | 0.0251 | 0.5 | |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0093 | 0.1618 | 0.1618 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0119 | 0.2393 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0149 | 0.328 | 0.328 |
Chlamydia trachomatis | glutamine binding protein | 0.0067 | 0.0829 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0119 | 0.2393 | 0.2393 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0119 | 0.2393 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0119 | 0.2393 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0149 | 0.328 | 0.5373 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0067 | 0.0829 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0067 | 0.0829 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.5889 | 1 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0278 | 0.7188 | 0.7188 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0119 | 0.2393 | 0.2635 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0149 | 0.328 | 0.328 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0235 | 0.5889 | 0.5889 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0292 | 0.7592 | 0.7592 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0067 | 0.0829 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0292 | 0.7592 | 0.7592 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0278 | 0.7188 | 0.7188 |
Brugia malayi | hypothetical protein | 0.0235 | 0.5889 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of human recombinant 17beta-HSD2 at 1 uM by cell-free assay | ChEMBL. | 19824648 | |
Inhibition (binding) | Inhibition of human recombinant 17beta-HSD2 at 0.1 uM by cell-free assay | ChEMBL. | 19824648 | |
Inhibition (binding) | = 16.7 % | Inhibition of human recombinant 17beta-HSD1 at 0.1 uM by cell-free assay | ChEMBL. | 19824648 |
Inhibition (binding) | = 67.2 % | Inhibition of human recombinant 17beta-HSD1 at 1 uM by cell-free assay | ChEMBL. | 19824648 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.