Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.7929 | 0.899 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0066 | 0.2014 | 0.2014 |
Schistosoma mansoni | thyroid hormone receptor | 0.0153 | 0.882 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0153 | 0.882 | 0.882 |
Schistosoma mansoni | jumonji domain containing protein | 0.0066 | 0.2014 | 0.2283 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0066 | 0.2014 | 0.2014 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0141 | 0.7929 | 0.7929 |
Brugia malayi | jmjC domain containing protein | 0.0066 | 0.2014 | 0.2014 |
Schistosoma mansoni | thyroid hormone receptor | 0.0153 | 0.882 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0066 | 0.2014 | 0.2283 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0141 | 0.7929 | 0.7929 |
Brugia malayi | jmjC domain containing protein | 0.0066 | 0.2014 | 0.2014 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0066 | 0.2014 | 0.2014 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0066 | 0.2014 | 0.2014 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0066 | 0.2014 | 0.2283 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 20 mm | Antibacterial activity against Escherichia coli at 2 mg/ml after 24 hrs by agar diffusion assay | ChEMBL. | 19570595 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.