Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cryptococcus neoformans var. neoformans B-3501A | Imidazoleglycerol-phosphate dehydratase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium leprae | Probable imidazole glycerol-phosphate dehydratase HisB | Get druggable targets OG5_129258 | All targets in OG5_129258 |
Candida albicans | Imidazole glycerol phosphate dehydratase | Get druggable targets OG5_129258 | All targets in OG5_129258 |
Mycobacterium ulcerans | imidazoleglycerol-phosphate dehydratase | Get druggable targets OG5_129258 | All targets in OG5_129258 |
Candida albicans | Imidazole glycerol phosphate dehydratase | Get druggable targets OG5_129258 | All targets in OG5_129258 |
Mycobacterium tuberculosis | Probable imidazole glycerol-phosphate dehydratase HisB | Get druggable targets OG5_129258 | All targets in OG5_129258 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Nanchung homolog | Imidazoleglycerol-phosphate dehydratase | 202 aa | 162 aa | 19.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0139 | 0.113 | 0.1338 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0246 | 0.2574 | 0.6495 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0125 | 0.0942 | 0.1116 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0246 | 0.2574 | 0.6495 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0541 | 0.6527 | 0.6527 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0139 | 0.113 | 0.1338 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0125 | 0.0942 | 0.1116 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0125 | 0.0942 | 0.1116 |
Leishmania major | mitochondrial DNA polymerase beta | 0.035 | 0.3963 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0125 | 0.0942 | 0.1116 |
Brugia malayi | hypothetical protein | 0.0175 | 0.1615 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0056 | 0.0022 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0184 | 0.1739 | 0.206 |
Plasmodium vivax | glutathione reductase, putative | 0.0055 | 0 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.035 | 0.3963 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0139 | 0.113 | 0.1338 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.035 | 0.3963 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0165 | 0.1488 | 0.3755 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.004 | 0.0247 |
Onchocerca volvulus | 0.0175 | 0.1615 | 0.5 | |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0541 | 0.6527 | 0.6527 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.004 | 0.0247 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.006 | 0.007 | 0.0176 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0165 | 0.1488 | 0.3755 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.004 | 0.0247 |
Mycobacterium tuberculosis | Probable imidazole glycerol-phosphate dehydratase HisB | 0.0683 | 0.8443 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0165 | 0.1488 | 0.3755 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0139 | 0.113 | 0.0657 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0055 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.1615 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0055 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.004 | 0.0247 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0799 | 1 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0125 | 0.0942 | 0.1116 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0799 | 1 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.0541 | 0.6527 | 0.6527 |
Mycobacterium ulcerans | imidazoleglycerol-phosphate dehydratase | 0.0683 | 0.8443 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0541 | 0.6527 | 0.6527 |
Leishmania major | hypothetical protein, conserved | 0.0246 | 0.2574 | 0.6495 |
Plasmodium falciparum | glutathione reductase | 0.0055 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0125 | 0.0942 | 0.1116 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0246 | 0.2574 | 0.6495 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.035 | 0.3963 | 1 |
Mycobacterium leprae | Probable imidazole glycerol-phosphate dehydratase HisB | 0.0337 | 0.3791 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.9 uM | Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans | ChEMBL. | 10450980 |
IC50 (binding) | = 3.9 uM | Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans | ChEMBL. | 10450980 |
Ki (binding) | = 0.8 uM | Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans | ChEMBL. | 10450980 |
Ki (binding) | = 0.8 uM | Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans | ChEMBL. | 10450980 |
Kis (binding) | = 6.1 uM | Kinetic constant for the inhibition of imidazole glycerol phosphate dehydratase (IGPD) | ChEMBL. | 10450980 |
Kis (binding) | = 6.1 uM | Kinetic constant for the inhibition of imidazole glycerol phosphate dehydratase (IGPD) | ChEMBL. | 10450980 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.