Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | trypanothione reductase | 0.0049 | 0.254 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3698 | 0.3494 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0111 | 0.6906 | 0.8837 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.3698 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0111 | 0.6906 | 0.8837 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0017 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0049 | 0.254 | 0.2985 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0313 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0.254 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0017 | 0.0313 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.3698 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0017 | 0.0313 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0.254 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0111 | 0.6906 | 0.8837 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.3698 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0049 | 0.254 | 0.658 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0.0313 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.3698 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0.254 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0017 | 0.0313 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3698 | 0.3494 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0313 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3698 | 0.3494 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0.254 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0049 | 0.254 | 0.658 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0111 | 0.6906 | 0.8837 |
Brugia malayi | RNA binding protein | 0.0065 | 0.3698 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0111 | 0.6906 | 0.8837 |
Treponema pallidum | NADH oxidase | 0.0017 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0123 | 0.7773 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0123 | 0.7773 | 1 |
Leishmania major | trypanothione reductase | 0.0049 | 0.254 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0017 | 0.0313 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.254 | 0.687 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.254 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.3698 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0017 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0111 | 0.6906 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0123 | 0.7773 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0017 | 0.0313 | 0.0848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3698 | 0.3494 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.3698 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.254 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0123 | 0.7773 | 1 |
Brugia malayi | glutathione reductase | 0.0049 | 0.254 | 0.687 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3698 | 0.3494 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.3698 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 45.7 ug ml-1 | Inhibition of Magnaporthe grisea isocitrate lyase | ChEMBL. | 18973387 |
LC50 (functional) | = 0.97 ug ml-1 | Cytotoxicity against human K562 cells after 48 hrs by SRB assay | ChEMBL. | 18973387 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by twofold dilution method | ChEMBL. | 18973387 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.