Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Angiotensin-converting enzyme | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Brugia malayi | Angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.3477 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.3477 | 1 | 0.5 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0749 | 0.1533 | 0.1533 |
Echinococcus granulosus | glycogen phosphorylase | 0.3477 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.1503 | 0.3875 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.3477 | 1 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.3477 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.3477 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.3477 | 1 | 1 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0749 | 0.1533 | 0.1533 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.3477 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.3477 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.3477 | 1 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.1503 | 0.3875 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.3477 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.3477 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.3477 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.3477 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.3477 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.3477 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.095 uM kg-1 | In vivo inhibition of angiotensin I induced pressor effect after iv administration in rats | ChEMBL. | 3336020 |
I50 (binding) | = 150 nM | In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippurylhistidylleucine as substrate | ChEMBL. | 3336020 |
IC50 (binding) | = 150 nM | In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippurylhistidylleucine as substrate | ChEMBL. | 3336020 |
Inhibition (functional) | = 69 % | In vivo inhibition angiotensin I induced pressor effect after po administrationof 5 umol/kg in rats | ChEMBL. | 3336020 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.