Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.3031 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0.3031 | 0.3031 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.3031 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.3031 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.6687 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.3031 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.6687 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.3031 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.3031 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.6687 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.3031 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.6687 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.3031 | 0.5 |
Brugia malayi | hypothetical protein | 0.004 | 0.6687 | 0.6687 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Inhibition of human SGLT2 expressed in HEK293.ETN cells assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake at 1 uM by scintillation counting | ChEMBL. | 19700318 |
Inhibition (binding) | = 38 % | Inhibition of human SGLT1 expressed in african green monkey COS7 cells assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake at 100 uM by scintillation counting | ChEMBL. | 19700318 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.