Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | DNA polymerase I (polA) | 0.0058 | 0.015 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.1856 | 0.7247 | 0.5 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0058 | 0.015 | 0.5 |
Chlamydia trachomatis | DNA polymerase I | 0.0058 | 0.015 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0698 | 0.2673 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0698 | 0.2673 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0698 | 0.2673 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0698 | 0.2673 | 1 |
Mycobacterium ulcerans | DNA polymerase I | 0.0058 | 0.015 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0058 | 0.015 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0698 | 0.2673 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0058 | 0.015 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0698 | 0.2673 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0698 | 0.2673 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0698 | 0.2673 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Mortality inhibition (functional) | = 0 % | In vitro leishmanicidal activity of the compound against promastigotes of L. donovani at 100 microg/ml concentration | ChEMBL. | No reference |
Mortality inhibition (functional) | = 0 % | In vitro leishmanicidal activity of the compound against promastigotes of L. donovani at 100 microg/ml concentration | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.