Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Endochitinase | 0.0594 | 1 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0594 | 1 | 1 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0499 | 0 | 0.5 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0499 | 0 | 0.5 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0508 | 0.0933 | 0.1029 |
Mycobacterium tuberculosis | Possible chitinase | 0.0499 | 0 | 0.5 |
Entamoeba histolytica | chitinase, putative | 0.0585 | 0.9067 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0594 | 1 | 1 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0585 | 0.9067 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0594 | 1 | 1 |
Loa Loa (eye worm) | chitinase I | 0.0585 | 0.9067 | 1 |
Leishmania major | chitinase | 0.0585 | 0.9067 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 250 ug ml-1 | Inhibition of Penicillin-binding protein 1 (PBP1) from Staphylococcus aureus | ChEMBL. | 11514150 |
IC50 (binding) | > 250 ug ml-1 | Inhibition of Penicillin-binding protein 2 (PBP2) from Staphylococcus aureus | ChEMBL. | 11514150 |
IC50 (binding) | > 250 ug ml-1 | Inhibition of Penicillin-binding protein 3 (PBP3) from Staphylococcus aureus | ChEMBL. | 11514150 |
IC50 (binding) | > 250 ug ml-1 | Inhibition of Penicillin-binding protein 1 (PBP1) from Staphylococcus aureus | ChEMBL. | 11514150 |
IC50 (binding) | > 250 ug ml-1 | Inhibition of Penicillin-binding protein 2 (PBP2) from Staphylococcus aureus | ChEMBL. | 11514150 |
IC50 (binding) | > 250 ug ml-1 | Inhibition of Penicillin-binding protein 3 (PBP3) from Staphylococcus aureus | ChEMBL. | 11514150 |
MIC (functional) | > 100 ug ml-1 | In vitro antibacterial activity against Enterobacter cloacae | ChEMBL. | 11514150 |
MIC (functional) | > 100 ug ml-1 | In vitro antibacterial activity against Moraxella catarrhalis | ChEMBL. | 11514150 |
MIC (functional) | > 100 ug ml-1 | In vitro antibacterial activity against Klebsiella pneumoniae | ChEMBL. | 11514150 |
T1/2 (ADMET) | = 11.9 hr | Half life period of the compound was measured at pH 7.4 in phosphate buffer | ChEMBL. | 11514150 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.