Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 35.3 uM | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | ChEMBL. | 20014857 |
CC50 (ADMET) | = 874 uM | Cytotoxicity against human KB cells after 72 hrs by alamar blue assay | ChEMBL. | 20014857 |
IC50 (functional) | = 82 nM | Antimalarial activity against drug-sensitive Plasmodium falciparum 3D7 assessed as [3H]hypoxanthine incorporation by scintillation counting | ChEMBL. | 20014857 |
Ratio IC50 (functional) | = 0.2 | Resistance index, ratio of IC50 for chloroquine-resistant Plasmodium falciparum K1 to IC50 for drug-sensitive Plasmodium falciparum 3D7 | ChEMBL. | 20014857 |
Ratio IC50 (functional) | = 0.5 | Resistance index, ratio of IC50 for chloroquine-resistant Plasmodium falciparum FcB1 to IC50 for drug-sensitive Plasmodium falciparum 3D7 | ChEMBL. | 20014857 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20014857 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.