Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.8652 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0297 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1042 | 0.1204 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0057 | 0.1671 | 0.1932 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0495 | 0.0573 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1042 | 0.1204 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1235 | 0.1427 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0056 | 0.1628 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1042 | 0.0973 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1235 | 0.1427 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1042 | 0.1207 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0495 | 0.0259 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0056 | 0.1628 | 1 |
Echinococcus granulosus | geminin | 0.0164 | 0.684 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1235 | 0.1427 |
Giardia lamblia | Kinase, PLK | 0.0056 | 0.1628 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1042 | 0.1138 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.684 | 0.8547 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.0131 | 0.5241 | 0.7556 |
Trypanosoma brucei | polo-like protein kinase | 0.0056 | 0.1628 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1042 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0495 | 0.0573 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0297 | 0.0344 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1042 | 0.1207 |
Schistosoma mansoni | kinase | 0.0187 | 0.7953 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0056 | 0.1628 | 0.1881 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1235 | 0.1427 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0056 | 0.1628 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0297 | 0.0344 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.684 | 0.8547 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0056 | 0.1628 | 0.1881 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1042 | 0.1138 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0056 | 0.1628 | 0.2095 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.8652 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1042 | 0.0973 |
Echinococcus multilocularis | geminin | 0.0164 | 0.684 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0056 | 0.1628 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0297 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0297 | 0.0078 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.0131 | 0.5241 | 0.7575 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0056 | 0.1628 | 0.2033 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.1628 | 0.1738 |
Brugia malayi | Cytochrome P450 family protein | 0.0057 | 0.1671 | 0.1932 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0056 | 0.1628 | 0.1371 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.