Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.5847 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0111 | 0.5847 | 0.5 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.0493 | 0.0119 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.0493 | 0.0119 |
Onchocerca volvulus | 0.0062 | 0.1742 | 0.2749 | |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0111 | 0.5847 | 0.5683 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0053 | 0.0998 | 0.1408 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0112 | 0.5949 | 0.5789 |
Brugia malayi | Hemopexin family protein | 0.0062 | 0.1742 | 0.27 |
Brugia malayi | jmjC domain containing protein | 0.0112 | 0.5949 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1428 | 0.2194 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0111 | 0.5847 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.2443 | 0.3987 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0044 | 0.0186 | 0.0318 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0111 | 0.5847 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0053 | 0.0998 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0111 | 0.5847 | 0.9823 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0998 | 0.1434 |
Onchocerca volvulus | Matrilysin homolog | 0.0097 | 0.4721 | 0.8011 |
Plasmodium vivax | transporter, putative | 0.0091 | 0.4219 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0159 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.1742 | 0.298 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0111 | 0.5847 | 0.5 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0131 | 0.7594 | 0.75 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0112 | 0.5949 | 0.5789 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0111 | 0.5847 | 0.5683 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0111 | 0.5847 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0097 | 0.4721 | 0.8011 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0053 | 0.0998 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.5847 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0379 | 0.0647 |
Giardia lamblia | Kinase, PLK | 0.0111 | 0.5847 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.5847 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.5847 | 1 |
Brugia malayi | Matrixin family protein | 0.0106 | 0.5465 | 0.9161 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0379 | 0.0647 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0111 | 0.5847 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0091 | 0.4219 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0379 | 0.0334 |
Loa Loa (eye worm) | matrixin family protein | 0.0106 | 0.5465 | 0.9326 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.5847 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0379 | 0.034 |
Schistosoma mansoni | jumonji domain containing protein | 0.0089 | 0.3999 | 0.684 |
Plasmodium vivax | hypothetical protein, conserved | 0.0091 | 0.4219 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.5847 | 1 |
Plasmodium vivax | serine-repeat antigen 4 (SERA) | 0.0091 | 0.4219 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0379 | 0.0647 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0111 | 0.5847 | 0.5 |
Schistosoma mansoni | kinase | 0.0056 | 0.1232 | 0.2107 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0111 | 0.5847 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0097 | 0.4721 | 0.8011 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0111 | 0.5847 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0053 | 0.0998 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 366 uM | Inhibition of Pseudomonas aeruginosa LasB by fluorimetric assay in buffer of pH 7.2 | ChEMBL. | 19773163 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.