Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | caspase-7 (C14 family) | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | caspase 2 | 0.0031 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0031 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 30 uM | Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation after 1 hr by fluorescence assay | ChEMBL. | 20638279 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.