Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinesin-5 | 0.0356112 | 0.131062 | 0.5 |
Echinococcus granulosus | kinesin family 1 | 0.269633 | 1 | 1 |
Plasmodium vivax | kinesin-5 | 0.0356112 | 0.131062 | 0.5 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0356112 | 0.131062 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0356112 | 0.131062 | 0.151033 |
Entamoeba histolytica | kinesin, putative | 0.0356112 | 0.131062 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.0356112 | 0.131062 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.269633 | 1 | 1 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0356112 | 0.131062 | 0.5 |
Brugia malayi | Kinesin motor domain containing protein | 0.0356112 | 0.131062 | 1 |
Schistosoma mansoni | hypothetical protein | 0.234021 | 0.867773 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 0.7152 uM | ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
EC50 (functional) | 1.1138 uM | ST_JUDE: Cytotoxicity against Plasmodium falciparum Dd2 | ChEMBL. | 20485428 |
EC50 (functional) | 1.262 uM | ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
EC50 (functional) | 1.2863 uM | ST_JUDE: Cytotoxicity against Plasmodium falciparum W2 | ChEMBL. | 20485428 |
EC50 (functional) | 1.4288 uM | ST_JUDE: Cytotoxicity against Plasmodium falciparum K1 | ChEMBL. | 20485428 |
EC50 (functional) | 2.0937 uM | ST_JUDE: Cytotoxicity against Plasmodium falciparum V1/S | ChEMBL. | 20485428 |
EC50 (functional) | 2.1973 uM | ST_JUDE: Cytotoxicity against Plasmodium falciparum 3D7 | ChEMBL. | 20485428 |
EC50 (functional) | 3.7254 uM | ST_JUDE: Cytotoxicity using luciferase to measure ATP as an indicator of the viability of Trypanosoma brucei | ChEMBL. | 20485428 |
EC50 (functional) | 4.6662 uM | ST_JUDE: Cytotoxicity against Plasmodium falciparum SB-A6 | ChEMBL. | 20485428 |
EC50 (functional) | 6.5698 uM | ST_JUDE: Cytotoxicity against Plasmodium falciparum D10 transfected with yeast DHOD | ChEMBL. | 20485428 |
EC50 | 6.9776 uM | ST_JUDE: Cytotoxicity using luciferase to measure ATP as an indicator of the viability of human epithelial hepatocellular carcinoma cells (HepG2) | ChEMBL. | 20485428 |
EC50 | 12.6142 uM | ST_JUDE: Cytotoxicity using luciferase to measure ATP as an indicator of the viability of human Burkitt''s lymphoma lymphoblast cells (Raji) | ChEMBL. | 20485428 |
EC50 (functional) | 13.8577 uM | ST_JUDE: Growth inhibition of to Toxoplasma gondii, in human U-2OS cells, as measured by luciferase. | ChEMBL. | 20485428 |
EC50 | 16.8339 uM | ST_JUDE: Cytotoxicity using luciferase to measure ATP as an indicator of the viability of human foreskin fibroblast cells (BJ) | ChEMBL. | 20485428 |
EC50 | 20.2776 uM | ST_JUDE: Cytotoxicity using luciferase to measure ATP as an indicator of the viability of human epithelial embryonic kidney cells (HEK293) | ChEMBL. | 20485428 |
EC50 (functional) | > 23.4 uM | ST_JUDE: Cytotoxicity using Alamar Blue to measure viability of Leishmania major | ChEMBL. | 20485428 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 20485428 | ||
Toxoplasma gondii | ChEMBL23 | 20485428 | |
Plasmodium falciparum | ChEMBL23 | 20485428 | |
Trypanosoma brucei | ChEMBL23 | 20485428 | |
Homo sapiens | ChEMBL23 | 20485428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.