Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, KQT-like subfamily, member 3 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, KQT-like subfamily, member 2 | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0042 | 0.0262 | 0.0216 |
Schistosoma mansoni | ap endonuclease | 0.0042 | 0.0262 | 0.0216 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0042 | 0.0262 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0141 | 0.3823 | 0.3794 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0042 | 0.0262 | 0.5 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0307 | 0.981 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.3823 | 0.3868 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0042 | 0.0262 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0248 | 0.7666 | 0.7804 |
Onchocerca volvulus | 0.0282 | 0.8895 | 1 | |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0042 | 0.0262 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0042 | 0.0262 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0042 | 0.0262 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0313 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0042 | 0.0262 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.0313 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.4994 | 0.497 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0042 | 0.0262 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.4994 | 0.497 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0042 | 0.0262 | 0.0262 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.0141 | 0.3823 | 0.3868 |
Echinococcus granulosus | geminin | 0.0173 | 0.4994 | 0.4994 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0042 | 0.0262 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0248 | 0.7666 | 0.7655 |
Echinococcus granulosus | potassium voltage gated channel subfamily KQT | 0.0141 | 0.3823 | 0.3823 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0042 | 0.0262 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0042 | 0.0262 | 0.0216 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0042 | 0.0262 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0042 | 0.0262 | 0.0216 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0042 | 0.0262 | 0.5 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.0313 | 1 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0282 | 0.8895 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0042 | 0.0262 | 1 |
Echinococcus multilocularis | geminin | 0.0173 | 0.4994 | 0.497 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.3823 | 0.3868 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0042 | 0.0262 | 0.0221 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | Anticonvulsant activity against maximal electroshock-induced seizures in po dosed CD1 mouse model treated 30 mins before electroshock application | ChEMBL. | 20020710 | |
EC50 (binding) | = 0.044 uM | Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay | ChEMBL. | 20020710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.